Abstract:Source of materialNovobiocin (0.613 g, 0.001 mol) and dibromozinc (1.126 g, 0.005 mol) were carefully dissolved in 20 mL of hot ethanoic acid and maintained 24 hours at 50 °C. Cyclonovobiocin crystallized as translucent needles. A suitable crystal was taken for diffraction studies.
DiscussionNovobiocin is a coumarin antibiotic first discovered in Streptomyces spheroides [1]. The biological activity is due to the inhibition of bacterial DNA gy rase [ 1 ]. Recent works demonstrated that novobiocin can bind to th… Show more
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