Crystal structure of glycerol kinase from Trypanosoma cruzi, a potential molecular target in Chagas disease
Oskar Lipiński,
Ravi R. Sonani,
Grzegorz Dubin
Abstract:Chagas disease is a neglected tropical disease caused by the protozoan parasite Trypanosoma cruzi. It bears a significant global health burden with limited treatment options, thus calling for the development of new and effective drugs. Certain trypanosomal metabolic enzymes have been suggested to be druggable and valid for subsequent inhibition. In this study, the crystal structure of glycerol kinase from T. cruzi, a key enzyme in glycerol metabolism in this parasite, is presented. Structural analysis allowed … Show more
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