2013
DOI: 10.1073/pnas.1300524110
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Crystal structure of glycoprotein E2 from bovine viral diarrhea virus

Abstract: Pestiviruses, including bovine viral diarrhea virus, are important animal pathogens and are closely related to hepatitis C virus, which remains a major global health threat. They have an outer lipid envelope bearing two glycoproteins, E1 and E2, required for cell entry. They deliver their genome into the host cell cytoplasm by fusion of their envelope with a cellular membrane. The crystal structure of bovine viral diarrhea virus E2 reveals a unique protein architecture consisting of two Ig-like domains followe… Show more

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Cited by 112 publications
(131 citation statements)
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“…Thus, in a more general sense, our findings here and in our previous work (18) support cumulative evidence indicating that the members of the different genera of the Flaviviridae family do not share a fusion mechanism (35,36). Differences in the crystal structures of the BVDV1 and HCV E2 glycoproteins illustrate that common genome arrangement among members of the Flaviviridae family does not translate to structurally similar fusion glycoproteins (29,30). Conversely, structural comparisons indicate that sequences showing marginal homology can display a common class II fold (e.g., dengue virus E and Semliki Forest virus E1 proteins) (37,38).…”
Section: Discussionsupporting
confidence: 88%
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“…Thus, in a more general sense, our findings here and in our previous work (18) support cumulative evidence indicating that the members of the different genera of the Flaviviridae family do not share a fusion mechanism (35,36). Differences in the crystal structures of the BVDV1 and HCV E2 glycoproteins illustrate that common genome arrangement among members of the Flaviviridae family does not translate to structurally similar fusion glycoproteins (29,30). Conversely, structural comparisons indicate that sequences showing marginal homology can display a common class II fold (e.g., dengue virus E and Semliki Forest virus E1 proteins) (37,38).…”
Section: Discussionsupporting
confidence: 88%
“…However, CSFV E2 glycoprotein does not adopt a canonical class II fold, and the FPII loop, although exposed, is not located at the tip of the molecule (29,30). Thus, in a more general sense, our findings here and in our previous work (18) support cumulative evidence indicating that the members of the different genera of the Flaviviridae family do not share a fusion mechanism (35,36).…”
Section: Discussionsupporting
confidence: 83%
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“…1A (2,5,6). Structural studies are available for nonstructural protein 5B (NS5B) (7), E rns (8), E2 (9,10), and N pro (11,12). N pro and E rns are unique to pestiviruses, while all the others have their counterparts in the other genera.…”
mentioning
confidence: 99%