Crystal structure of methyl 1-(4-fluorobenzyl)-4-methoxy-5-oxopyrrolidine-3-carboxylate, C₁₄H₁₆FNO₄

Abstract

CCDC no.: 1514594The crystal structure is shown in the figure. Tables 1 and 2 contain details on crystal structure and measurement conditions and a list of the atoms including atomic coordinates and displacement parameters. Source of materialDimethyl 2-methoxy-3-methylenesuccinate (0.3 g, 1.58 mmol) was dissolved in 6 mL of MeOH followed by dropwise addition of 4-fluorobenzylamine (1.58 mmol, 1 equiv.) under a nitrogen atmosphere at 0°C. The mixture was then stirred vigorously at this temperature during 6 h. The solvent was concentrated under reduced pressure, and the crude product Experimental detailsThe structure was solved by Direct Methods [2] and the refinement was done against F 2 [2]. The reflections were corrected for Lorentz and polarization effects followed by psi-scan absorption correction [3]. DiscussionHighly functionalized pyrrolidines have gained much interest in the past years as they constitute the structural element of