Crystal Structure of Phosphoserine BlaC from Mycobacterium tuberculosis Inactivated by Bis(Benzoyl) Phosphate

Moural, Timothy W.; White, Dawanna S.; Choy, Cindy J.; Kang, ChulHee; Berkman, Clifford E.

doi:10.3390/ijms20133247

Cited by 2 publications

(3 citation statements)

References 43 publications

(69 reference statements)

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“…Multiple instances of insecticide resistance have been reported resulting from overexpression and/or mutation events in α-esterases [ 51 , 74 ]. The inactivation of esterase enzymes can occur upon exposure to OPs via phosphorylation of the active site serine [ 76 ]. Mutations that alter the active site can lead to the gained ability of the enzyme to overcome inactivation upon exposure to OPs.…”

Section: Cce Classification and Structural Characteristicsmentioning

confidence: 99%

Dynamic Roles of Insect Carboxyl/Cholinesterases in Chemical Adaptation

Cruse

Moural

Zhu

2023

Insects

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Insects have evolved several intricate defense mechanisms to adapt to their chemical environment. Due to their versatile capabilities in hydrolytic biotransformation, insect carboxyl/cholinesterases (CCEs) play vital roles in the development of pesticide resistance, facilitating the adaptation of insects to their host plants, and manipulating insect behaviors through the olfaction system. CCEs confer insecticide resistance through the mechanisms of qualitative or quantitative changes of CCE-mediated enhanced metabolism or target-site insensitivity, and may contribute to the host plant adaptation. CCEs represent the first odorant-degrading enzymes (ODEs) discovered to degrade insect pheromones and plant odors and remain the most promising ODE candidates. Here, we summarize insect CCE classification, currently characterized insect CCE protein structure characteristics, and the dynamic roles of insect CCEs in chemical adaptation.

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Section: Cce Classification and Structural Characteristicsmentioning

confidence: 99%

Dynamic Roles of Insect Carboxyl/Cholinesterases in Chemical Adaptation

Cruse

Moural

Zhu

2023

Insects

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“…Jumlah kasus baru TB di Indonesia sebanyak 420,994 kasus pada tahun 2017 (data per 17 Mei 2018). 3 Di Asia Tenggara, sekitar 74.000 orang meninggal karena koinfeksi HIV-TB dengan 12 kasus per 100.000 penduduk pada tahun 2015, dan Indonesia merupakan yang tercepat dengan rata-rata 63.000 kasus TB dengan HIV positif per tahun dengan tingkat mortalitas sebanyak 22.000 kasus per tahun. 3 Interaksi antara TB dan infeksi HIV merupakan interaksi yang komplek.…”

Section: Pendahuluanunclassified

“…3 Di Asia Tenggara, sekitar 74.000 orang meninggal karena koinfeksi HIV-TB dengan 12 kasus per 100.000 penduduk pada tahun 2015, dan Indonesia merupakan yang tercepat dengan rata-rata 63.000 kasus TB dengan HIV positif per tahun dengan tingkat mortalitas sebanyak 22.000 kasus per tahun. 3 Interaksi antara TB dan infeksi HIV merupakan interaksi yang komplek. Pada individu yang terinfeksi HIV keadaan ini akan menyebabkan penurunan sistem imun dan meningkatkan kerentanan akan kejadian TB.…”

Section: Pendahuluanunclassified

Korelasi Jumlah CD4 Pasien Yang Diberi Isoniazid Dengan Ko-infeksi TB Pada Pasien HIV/AIDS

Salim¹,

Zulfian

Hasbie

et al. 2020

arteri

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The interaction between TB and HIV infection is complex. In HIV-infected individuals, this situation will decrease the immune system and increase vulnerability to TB incidence. HIV causes reactivation, reinfection, and progression of latent TB infection to active tuberculosis. It also led to differences in the clinical presentation of TB in HIV patients, complications, and response to anti-TB treatment than in HIV negative patients. The purpose of this study To Know Correlation CD4 counts in patients with HIV / AIDS in hospitals Dr.H. Abdul Moeloek Lampung Province 2018. Research methods: cross-sectional approach, in which several variables tested in this research object data got from the medical record. Analysis of the data used is the Mann-Whitney statistical test. Research The total sample of 160 medical records of patients seen that the Asymp. Sig. (2-tailed) is 0,000. Half of this significance value ½ (0.000) is <0.05. It can be concluded that reject H0 and Ha accepted, which implies a significant difference in CD4 cell counts in patients given isoniazid as TB prevention with patients TB co-infection. With all forces, correlation means that their relationship CD4 cell counts in patients given isoniazid to prevent TB and TB co-infection. There is a significant relationship between CD4 cell count in patients who given isoniazid for the prevention of TB and TB co-infection in HIV / AIDS patients in hospitals Dr.H. Abdul Moeloek Lampung Province 2018.

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Crystal Structure of Phosphoserine BlaC from Mycobacterium tuberculosis Inactivated by Bis(Benzoyl) Phosphate

Cited by 2 publications

References 43 publications

Dynamic Roles of Insect Carboxyl/Cholinesterases in Chemical Adaptation

Dynamic Roles of Insect Carboxyl/Cholinesterases in Chemical Adaptation

Korelasi Jumlah CD4 Pasien Yang Diberi Isoniazid Dengan Ko-infeksi TB Pada Pasien HIV/AIDS

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