2020
DOI: 10.1002/pro.3980
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Crystal structure of the giant panda MHC class I complex: First insights into the viral peptide presentation profile in the bear family

Abstract: The viral cytotoxic T lymphocyte (CTL) epitope peptides presented by classical MHC-I molecules require the assembly of a peptide-MHC-I-β2m (pMHC-I) trimolecular complex for T cell receptor (TCR) recognition, which is the critical activation link for triggering antiviral T cell immunity. Research on T cell immunology in the Ursidae family, especially structural immunology, is still lacking. In this study, the structure of the key trimolecular complex pMHC-I, which binds a peptide from canine distemper virus, wa… Show more

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“…The unfolded fraction (%) is expressed as (θ − θN)/(θU − θN), where θN and θU are the mean residue ellipticity values in the fully folded and fully unfolded states, respectively. The Tm was determined by fitting the data to the denaturation curves using the Origin 8.0 program (OriginLab Northampton, MA, USA) as described [ 30 ].…”
Section: Methodsmentioning
confidence: 99%
“…The unfolded fraction (%) is expressed as (θ − θN)/(θU − θN), where θN and θU are the mean residue ellipticity values in the fully folded and fully unfolded states, respectively. The Tm was determined by fitting the data to the denaturation curves using the Origin 8.0 program (OriginLab Northampton, MA, USA) as described [ 30 ].…”
Section: Methodsmentioning
confidence: 99%