Crystal Structure of the N-Benzyloxycarbonyl-alanyl-phenylalanyl-methyl Ester: The Importance of the H-Bonding Pattern

Abstract

Large crystals of the methyl ester of the N-α-benzyloxycarbonyl protected AlaPhe dipeptide (Z-AF-OMe) were obtained after the very slow evaporation of a solution of the corresponding carboxylic acid (Z-AF-OH) in methanol containing an excess of HCl. The structure was confirmed by single crystal X-ray diffraction data. It crystallizes in the orthorhombic space group P2 1 2 1 2 1 with unit cell dimensions a = 5.0655 (6)