Crystal structure of the phospholipase A and acyltransferase 4 (PLAAT4) catalytic domain

Wehlin, Anna; Cornaciu, Irina; Márquez, José Antonio; Perrakis, Anastassis; Castelmur, Eleonore von

doi:10.1016/j.jsb.2022.107903

Cited by 1 publication

(1 citation statement)

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“…Similarly, the study of Yamamoto et al showed that nude mice after intrasplenic injection of pancreatic cancer cell lines (BxPC3) with KDM6B knocked down had a worse prognosis than nude mice after intrasplenic injection of BxPC3 cell lines without KDM6B knocked down 57 . PLAAT4 is a tumor suppressor induced by retinoids, and its high expression in cancer favors inhibiting the growth of cancer cells and promotes apoptosis 58 . However, PLAAT4 was highly expressed in PDAC tissues and related with worse prognosis of PDAC patients in the study of Li et al 59 .…”

Section: Discussionmentioning

confidence: 99%

Combining single-cell and bulk RNA sequencing, NK cell marker genes reveal a prognostic and immune status in pancreatic ductal adenocarcinoma

Ouyang,

Shen,

Chu

et al. 2024

Sci Rep

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The NK cell is an important component of the tumor microenvironment of pancreatic ductal adenocarcinoma (PDAC), also plays a significant role in PDAC development. This study aimed to explore the relationship between NK cell marker genes and prognosis, immune response of PDAC patients. By scRNA-seq data, we found the proportion of NK cells were significantly downregulated in PDAC and 373 NK cell marker genes were screened out. By TCGA database, we enrolled 7 NK cell marker genes to construct the signature for predicting prognosis in PDAC patients. Cox analysis identified the signature as an independent factor for pancreatic cancer. Subsequently, the predictive power of signature was validated by 6 GEO datasets and had an excellent evaluation. Our analysis of relationship between the signature and patients’ immune status revealed that the signature has a strong correlation with immunocyte infiltration, inflammatory reaction, immune checkpoint inhibitors (ICIs) response. The NK cell marker genes are closely related to the prognosis and immune capacity of PDAC patients, and they have potential value as a therapeutic target.

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Section: Discussionmentioning

confidence: 99%