Crystal structure of the transcriptional repressor PagR of Bacillus anthracis

Zhao, Haiyan; Volkov, Arsen; Veldore, Vidya Harini; Hoch, James A.; Varughese, Kottayil I.

doi:10.1099/mic.0.033548-0

Cited by 16 publications

(18 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…6 also contains proteins not known to bind metal; however, these two categories are clearly separated. There appears to be one exception -although placed with the metal-binding proteins, PagR (2zkz) has not been characterized to have this property [56]. Interestingly, PagR seems to undergo branching before that of metal-binding CzrA (1r1v) [12] or CadC (1u2w) [13].…”

Section: Evolution Of the Whth In Hlyumentioning

confidence: 96%

Crystal structure of HlyU, the hemolysin gene transcription activator, from Vibrio cholerae N16961 and functional implications

Mukherjee

Datta

Chakrabarti

2014

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics

View full text Add to dashboard Cite

Section: Evolution Of the Whth In Hlyumentioning

confidence: 96%

Crystal structure of HlyU, the hemolysin gene transcription activator, from Vibrio cholerae N16961 and functional implications

Mukherjee

Datta

Chakrabarti

2014

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics

View full text Add to dashboard Cite

“…For example, Vibrionaceae are well known as opportunistic pathogens in algae (Weinberger et al, 1994; Largo et al, 1995), crustaceans (Selvin and Lipton, 2003), mollusks (Liu et al, 2001; Paul-Pont et al, 2010), and fish (Martinez Diaz and Anguas Velez, 2002; Tian et al, 2008; Ye et al, 2008; Zhao et al, 2010). Under most circumstances, these Vibrionaceae are harmless to their hosts, but under specific–stressful–conditions they may turn virulent.…”

Section: Ecological Role Of Epibiotic Bacteria: Modulation Of Host-enmentioning

confidence: 99%

The Second Skin: Ecological Role of Epibiotic Biofilms on Marine Organisms

Wahl¹,

Goecke²,

Labes³

et al. 2012

Front. Microbio.

388

314

View full text Add to dashboard Cite

In the aquatic environment, biofilms on solid surfaces are omnipresent. The outer body surface of marine organisms often represents a highly active interface between host and biofilm. Since biofilms on living surfaces have the capacity to affect the fluxes of information, energy, and matter across the host’s body surface, they have an important ecological potential to modulate the abiotic and biotic interactions of the host. Here we review existing evidence how marine epibiotic biofilms affect their hosts’ ecology by altering the properties of and processes across its outer surfaces. Biofilms have a huge potential to reduce its host’s access to light, gases, and/or nutrients and modulate the host’s interaction with further foulers, consumers, or pathogens. These effects of epibiotic biofilms may intensely interact with environmental conditions. The quality of a biofilm’s impact on the host may vary from detrimental to beneficial according to the identity of the epibiotic partners, the type of interaction considered, and prevailing environmental conditions. The review concludes with some unresolved but important questions and future perspectives.

show abstract

“…Our data also suggest niche-specific roles for other, less-studied transcriptional regulators (COG functional category K) in B. quintana , such as BQ08990 and BQ06490. BQ08990 has homology to the ArsR family of transcriptional regulators, which has a role in sensing environmental metal concentrations, and in the induction of pathogenicity in Bacillus anthracis and Streptococcus mutans [41], [42], [43]. BQ06490 has homology to the AsnC transcriptional regulators that are typically involved in environmentally-cued induction of alternative amino acid metabolic pathways [44].…”

Section: Resultsmentioning

confidence: 99%

Bartonella quintana Deploys Host and Vector Temperature-Specific Transcriptomes

et al. 2013

View full text Add to dashboard Cite

The bacterial pathogen Bartonella quintana is passed between humans by body lice. B. quintana has adapted to both the human host and body louse vector niches, producing persistent infection with high titer bacterial loads in both the host (up to 105 colony-forming units [CFU]/ml) and vector (more than 108 CFU/ml). Using a novel custom microarray platform, we analyzed bacterial transcription at temperatures corresponding to the host (37°C) and vector (28°C), to probe for temperature-specific and growth phase-specific transcriptomes. We observed that transcription of 7% (93 genes) of the B. quintana genome is modified in response to change in growth phase, and that 5% (68 genes) of the genome is temperature-responsive. Among these transcriptional changes in response to temperature shift and growth phase was the induction of known B. quintana virulence genes and several previously unannotated genes. Hemin binding proteins, secretion systems, response regulators, and genes for invasion and cell attachment were prominent among the differentially-regulated B. quintana genes. This study represents the first analysis of global transcriptional responses by B. quintana. In addition, the in vivo experiments provide novel insight into the B. quintana transcriptional program within the body louse environment. These data and approaches will facilitate study of the adaptation mechanisms employed by Bartonella during the transition between human host and arthropod vector.

show abstract

Crystal structure of the transcriptional repressor PagR of Bacillus anthracis

Cited by 16 publications

References 23 publications

Crystal structure of HlyU, the hemolysin gene transcription activator, from Vibrio cholerae N16961 and functional implications

Crystal structure of HlyU, the hemolysin gene transcription activator, from Vibrio cholerae N16961 and functional implications

The Second Skin: Ecological Role of Epibiotic Biofilms on Marine Organisms

Bartonella quintana Deploys Host and Vector Temperature-Specific Transcriptomes

Contact Info

Product

Resources

About