Crystal structures and luminescence of two zinc(II) complexes with benzimidazole ligands

Miao, Shaobin; Ji, Baoming; Deng, Dongsheng; Xu, Chunying; Ma, Ning

doi:10.1007/s10947-010-0057-4

Cited by 5 publications

(1 citation statement)

References 14 publications

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“…The aromatic ring's C-H stretching vibration is blamed for the weak absorption at 3,074 cm -1 . The frequencies at 1,573 and 1,522 cm -1 can be assigned to the stretching of the bim and py rings (27). The absorptions between 900 and 600 cm -1 are mostly due to the C-H out-of-plane and N-H out-of-plane bends as well as the in-plane ring bending modes.…”

Section: Ft-ir Spectramentioning

confidence: 94%

Differential Cytotoxic Activity of a New Cationic Pd(II) Coordination Compound with N4-Tetradentate Hybrid Ligand in Cancer Cell Lines

Genel¹,

Selvi²,

Yılmaz³

et al. 2022

experimed

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Objective: Successful cancer treatment still requires the discovery of novel compounds that hold promise for chemotherapeutics. The objective of this study was to examine the effectiveness of a newly synthesized cationic palladium(II) coordination compound that functions via several pathways to provide an efficient therapeutic option for various cancer cells. Materials and Methods:A new cationic palladium(II) coordination compound, [Pd(L)]Cl 2 •H 2 O, denoted as Complex 1, where the ligand L is the compound 6,6'-bis(NH-benzimidazol-2-yl)-2,2'-bipyridine), was synthesized and characterized by the attenuated total reflectance (ATR) -fourier-transform infrared spectroscopy (FT-IR), proton nuclear magnetic resonance ( 1 H NMR), electrospray ionization mass spectrometry (ESI-MS), and carbon-hydrogen-nitrogen (CHN) analyses. The density functional theory (DFT) calculations show the coordination sphere around the metal center in Complex 1 to be made up of tertiary N atoms of the pyridine (py) and benzimidazole (bim) rings completing the square-planar geometry with significant distortion. The anti-growth/cytotoxic activity of the complex was determined using the sulforhodamine B (SRB) and adenosine triphosphate (ATP) viability assays for 24 and 48 h in vitro. The study evaluates the determinations for annexin V-propidium iodide (PI) positivity, mitochondrial membrane potential loss, Bcl-2 protein inactivation, and deoxyribonucleic acid (DNA) damage to investigate the cell death mode and its partial mechanism.Results: Complex 1 caused cytotoxicity in a dose-dependent manner in all the cell lines used, with IC 50 values ranging from 2.6-8.8 μM for 48 h. Among the cancer models, colon and breast cancer cell lines underwent cell death by well-described apoptosis through the intrinsic pathway involving the mitochondria. However, the other cell lines did not show such a cell death modality. This implies that differential cell death modes operate based on the cancer type. Conclusion:For the treatment of breast and colon cancers, the complex 1 appears to be a unique, promising complex. Therefore, complex 1 deserves further attention for proof of concept in animal models.

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Section: Ft-ir Spectramentioning

confidence: 94%