Crystal structures of (E)-N′-(2-hydroxy-5-methylbenzylidene)isonicotinohydrazide and (E)-N′-(5-fluoro-2-hydroxybenzylidene)isonicotinohydrazide

Abstract

The title isonicotinohydrazides adopt an E conformation about the C=N bonds and in each mol­ecule there is an intra­molecular O—H⋯N hydrogen bond, forming an S(6) ring motif. In the crystals of both compounds, zigzag chains are formed via N—H⋯N hydrogen bonds, in the [10] the first compound and [010] for the other.

Crystal structure of (E)-N′-(3-fluoro-2-hydroxybenzylidene)isonicotinohydrazide

“…Hydrazone-based chelators of metal ions are interesting compounds that receive a significant amount of interest (Bendová et al, 2010;Jansová et al, 2014;Hrušková et al, 2016). We have recently published the structures of two derivatives of the prototypical chelator from this class, salicyl aldehyde isonicotinoyl hydrazide (SIH), which were synthesized as potential sensors for metal ions (Chainok et al, 2016). The structures reported have fluorine and methyl substitution in position 5 on the benzene ring.…”