Crystal structures of three N,N,N′-trisubstituted thioureas for reactivity-controlled nanocrystal synthesis

Abstract

The synthesis and single-crystal X-ray structures of three N,N,N′-trisubstituted thioureas are reported, namely N,N,N′-tribenzylthiourea, C22H22N2S (1), N-methyl-N,N′-diphenylthiourea, C14H14N2S (2), and N,N-di-n-butyl-N′-phenylthiourea, C15H24N2S (3). The influence of the different substituents on the thioureas is clear from the delocalization of the thiourea C—N and C=S bonds, while the crystal structures show infinite chains of N,N,N′-tribenzylthiourea (1), hydrogen-bonded pairs of N-methyl-N,N′-diphenylthiourea (2) and hexamer ring assemblies of N,N-di-n-butyl-N′-phenylthiourea (3) molecules. The above-mentioned compounds were synthesized via a mild, general procedure, readily accessible precursors and with a high yield, providing straightforward access to a whole library of thioureas.

Binding Affinity of Monoalkyl Phosphinic Acid Ligands toward Nanocrystal Surfaces

“…N,N,N′ -tribenzylthiourea was synthesized as reported by Dhaene et al according to the procedure by Hendricks et al with an additional recrystallization step. , A 40 mL vial was loaded with benzylisothiocyanate (4476.6 mg, 3.8 mL, 30 mmol, 1 equiv) and toluene (5 mL). To this, a solution of dibenzylamine (5918.4 mg, 5.8 mL, 30 mmol, 1 equiv) in toluene (5 mL) was added dropwise and let to stir for 1 h. Afterward, the solvent was removed from the rotary evaporator, and the solid product was recrystallized in acetonitrile (30 mL) to obtain the purified thiourea in the form of white needles (15.6 g, 75%).…”

“…Synthesis of N,N,N′-Tribenzylthiourea. N,N,N′-tribenzylthiourea was synthesized as reported by Dhaene et al 88 according to the procedure by Hendricks et al with an additional recrystallization step. 79,89 A 40 mL vial was loaded with benzylisothiocyanate (4476.6 mg, 3.8 mL, 30 mmol, 1 equiv) and toluene (5 mL).…”