Crystal structures of two thiazolidinone derivatives bearing a trichloromethyl substituent at the 2-position

Abstract

The mol­ecular conformations of the racemic title mol­ecules are almost identical. Each crystal structure features a short C—H⋯O hydrogen bond arising from the chiral carbon atom, which generates monochiral chains, although the overall structures are centrosymmetric.

Crystal structures of two 1,3-thiazolidin-4-one derivatives featuring sulfide and sulfone functional groups

“…The N-C-S bond angle is found to be 105.22 (12) in structure 1 and 101.36 (7) in structure 2 indicating a compression of the N-C-S bond angle going from the sulfide to the sulfone. Bond length and angle values in the thiazolidinone ring of the sulfide appear to be typical and match data that we have previously reported (Nuriye et al, 2018). Although structural data for the sulfone are scarce, the data reported by Orsini et al (1995) matches our findings.…”

“…The title compounds were synthesized as a part of our ongoing work on the synthesis of new types of 2,3-disubstituted 1,3thiazolidin-4-ones. We have reported the crystal structures of a number of these compounds before (Nuriye et al, 2018;Yennawar et al, 2015). These compounds are synthesized by a tandem nucleophilic addition-carbonyl condensation of thioglycolic acid with the desired in situ-generated imine.…”