Crystal surface defects as possible origins of cocrystal dissociation

Eddleston, Mark D.; Chow, Ernest H. H.; Bučar, Dejan‐Krešimir; Thakuria, Ranjit

doi:10.1039/d2ce00166g

Cited by 2 publications

(2 citation statements)

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“…As an extension, Eddleston et al [149] . further investigated the cocrystal dissociation at the molecular level using in situ intermittent contact mode‐AFM (IC‐AFM) by exposing crystal faces of the two polymorphic forms under controlled humidity.…”

Section: Polymorphism In Pharmaceutical Materialsmentioning

confidence: 99%

“…As an extension, Eddleston et al [149] further investigated the cocrystal dissociation at the molecular level using in situ intermittent contact mode-AFM (IC-AFM) by exposing crystal faces of the two polymorphic forms under controlled humidity. IC-AFM images show dislocation sites on the surfaces of freshly cleaved single crystals of Form II, while such features were absent on the surface of the investigated single crystals of Form I (Figure 62).…”

Section: Polymorphism In Pharmaceutical Materialsmentioning

confidence: 99%

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Polymorphs with Remarkably Distinct Physical and/or Chemical Properties

Saha

Nath

Thakuria

2022

The Chemical Record

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Polymorphism in crystals is known since 1822 and the credit goes to Mitscherlich who realized the existence of different crystal structures of the same compound while working with some arsenate and phosphate salts. Later on, this phenomenon was observed also in organic crystals. With the advent of different technologies, especially the easy availability of single crystal XRD instruments, polymorphism in crystals has become a common phenomenon. Almost 37 % of compounds (single component) are polymorphic to date. As the energies of the different polymorphic forms are very close to each other, small changes in crystallization conditions might lead to different polymorphic structures. As a result, sometimes it is difficult to control polymorphism. For this reason, it is considered to be a nuisance to crystal engineering. It has been realized that the property of a material depends not only on the molecular structure but also on its crystal structure. Therefore, it is not only of interest to academia but also has widespread applications in the materials science as well as pharmaceutical industries. In this review, we have discussed polymorphism which causes significant changes in materials properties in different fields of solid-state science, such as electrical, magnetic, SHG, thermal expansion, mechanical, luminescence, color, and pharmaceutical. Therefore, this review will interest researchers from supramolecular chemistry, materials science as well as medicinal chemistry.

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Section: Polymorphism In Pharmaceutical Materialsmentioning

confidence: 99%

Section: Polymorphism In Pharmaceutical Materialsmentioning

confidence: 99%