Crystal violet as an i-motif structure probe for reversible and label-free pH-driven electrochemical switch

Zhang, Xi Yuan; Luo, Hong Qun; Li, Nian Bing

doi:10.1016/j.ab.2014.03.015

Cited by 11 publications

(6 citation statements)

References 30 publications

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“…In the same year, Kong et al demonstrated the end-loop protection mechanism of bound ligands in an antiparallel topology [120]. The stacking mechanism was also reported for CV interactions with i-motif [123].…”

Section: Fluorescent Turn-on G-quadruplex Ligandmentioning

confidence: 99%

G-Quadruplex-Based Fluorescent Turn-On Ligands and Aptamers: From Development to Applications

Umar

Chan

et al. 2019

Molecules

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Guanine (G)-quadruplexes (G4s) are unique nucleic acid structures that are formed by stacked G-tetrads in G-rich DNA or RNA sequences. G4s have been reported to play significant roles in various cellular events in both macro- and micro-organisms. The identification and characterization of G4s can help to understand their different biological roles and potential applications in diagnosis and therapy. In addition to biophysical and biochemical methods to interrogate G4 formation, G4 fluorescent turn-on ligands can be used to target and visualize G4 formation both in vitro and in cells. Here, we review several representative classes of G4 fluorescent turn-on ligands in terms of their interaction mechanism and application perspectives. Interestingly, G4 structures are commonly identified in DNA and RNA aptamers against targets that include proteins and small molecules, which can be utilized as G4 tools for diverse applications. We therefore also summarize the recent development of G4-containing aptamers and highlight their applications in biosensing, bioimaging, and therapy. Moreover, we discuss the current challenges and future perspectives of G4 fluorescent turn-on ligands and G4-containing aptamers.

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Section: Fluorescent Turn-on G-quadruplex Ligandmentioning

confidence: 99%

G-Quadruplex-Based Fluorescent Turn-On Ligands and Aptamers: From Development to Applications

Umar

Chan

et al. 2019

Molecules

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“…Recently, another application of thiol-modified cytosine-rich sequences has been reported. Here, crystal violet dye was used as a selective electrochemical probe for the i-motif structure because of its capacity to bind to the i-motif structure (Zhang et al, 2014). In acidic aqueous solution, crystal violet approached the electrode surface owing to the formation of the i-motif structure, resulting in a strong signal.…”

Section: Electrochemistry-based Ph Analysismentioning

confidence: 99%

Nucleic Acid i-Motif Structures in Analytical Chemistry

Alba

Sadurní

Gargallo

2016

Critical Reviews in Analytical Chemistry

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Under the appropriate experimental conditions of pH and temperature, cytosine-rich segments in DNA or RNA sequences may produce a characteristic folded structure known as an i-motif. Besides its potential role in vivo, which is still under investigation, this structure has attracted increasing interest in other fields due to its sharp, fast and reversible pH-driven conformational changes. This "on/off" switch at molecular level is being used in nanotechnology and analytical chemistry to develop nanomachines and sensors, respectively. This paper presents a review of the latest applications of this structure in the field of chemical analysis.

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“…[17][18][19] From the aspect of environmental safety and health of life, it is vital to develop an effective way to abate CV in wastewater. Various methods have been adopted for eliminating dye pollution from water, including chemical oxidation, 20,21 photo-catalytic decomposition, 22,23 electro-catalytic degradation 24,25 and non-thermal plasma. [26][27][28] These methods usually have some defects, such as slow degradation rate, complex, heavy expenses and usually causing secondary pollution.…”

Section: Introductionmentioning

confidence: 99%

One-step preparation of a novel SrCO₃/g-C₃N₄ nano-composite and its application in selective adsorption of crystal violet

et al. 2018

RSC Adv.

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Crystal violet as an i-motif structure probe for reversible and label-free pH-driven electrochemical switch

Cited by 11 publications

References 30 publications

G-Quadruplex-Based Fluorescent Turn-On Ligands and Aptamers: From Development to Applications

G-Quadruplex-Based Fluorescent Turn-On Ligands and Aptamers: From Development to Applications

Nucleic Acid i-Motif Structures in Analytical Chemistry

One-step preparation of a novel SrCO₃/g-C₃N₄ nano-composite and its application in selective adsorption of crystal violet

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Crystal violet as an i-motif structure probe for reversible and label-free pH-driven electrochemical switch

Cited by 11 publications

References 30 publications

G-Quadruplex-Based Fluorescent Turn-On Ligands and Aptamers: From Development to Applications

G-Quadruplex-Based Fluorescent Turn-On Ligands and Aptamers: From Development to Applications

Nucleic Acid i-Motif Structures in Analytical Chemistry

One-step preparation of a novel SrCO3/g-C3N4 nano-composite and its application in selective adsorption of crystal violet

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One-step preparation of a novel SrCO₃/g-C₃N₄ nano-composite and its application in selective adsorption of crystal violet