Crystallinity investigation of poorly soluble drugs dispersed in paper using terahertz time-domain spectroscopy

Abstract

We use terahertz time-domain spectroscopy for non-destructive crystallinity investigation of poorly soluble drugs loaded into paper. Our results underline the great potential of terahertz spectroscopy as an analytical tool to study pharmaceutical formulations.

Novel SmartReservoirs for hydrogel-forming microneedles to improve the transdermal delivery of rifampicin

“…2) that restrict crystal growth or the potential interactions within the SF matrix. 38,65,66 Hence, the quantity of drug loaded into the SFs is dependent on the number of pores, as an amount exceeding the pore capacity will result in re-crystallization of API on the cellulose fibres. 67 This was observed in the SEM images (Fig.…”

“…32,35,36 A recent technology with high loading efficiency is Smart-Films s (SF), composed of cellulose based matrices that maintain the active pharmaceutical ingredient (API) in its amorphous form. 32,[37][38][39] Previously, Eckert et al modelled the delivery of curcumin, a hydrophobic drug molecule, using SF-technology. 32 They reported a significant improvement in the solubility of curcumin using SF, leading to the successful incorporation of the hydrophobic molecule in its amorphous form within the cellulose matrix.…”