Crystallinity of Dynasan®114 and Dynasan®118 matrices for the production of stable Miglyol®-loaded nanoparticles

Severino, Patrícia; Pinho, Samantha C.; Souto, Eliana B.; Santana, Maria Helena Andrade

doi:10.1007/s10973-011-1613-7

Cited by 29 publications

(18 citation statements)

References 30 publications

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“…The calculated p-value was compared with the tabulated p-value to check for significant difference in release on 114 respectively. [28][29][30][31][32] Presence of separate peaks of the drug and lipids in the binary mixture graphs clearly indicates no incompatibility between the drug and the lipids.…”

Section: Statistical Analysis Usedmentioning

confidence: 99%

Comparison of Release Retardant Effect of Some Novel Lipids by Formulating Sustained Release Tablet of BCS Class 1 Drug

Devi¹,

Sharma²,

Sharma³

et al. 2020

IJPER

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Aim: The study was carried out with the objective of comparing the release retardant effect of some novel lipids by preparing sustained release tablets of highly watersoluble drug, theophylline. Methods: The tablets were a mixture of theophylline and each of the three novel lipids taken in different ratios (Compritol ATO 888, Precirol ATO 5, Dynasan 114) prepared by Direct compression method. Drug and novel lipids interaction was determined by FTIR spectroscopy and DSC while drug release from the sustained release tablets was studied using USP-ll dissolution apparatus. The release was analysed to determine the lipid showing the best retardant effect. It was also subjected to different kinetic models to evaluate the release kinetics and mechanism of release. Statistical analysis was done on in-vitro release data by ordinary one-way ANOVA to check for significant difference in release for different formulation. The hardness and other evaluation parameters of the tablets were within acceptable range. Results: FTIR and DSC showed no interaction between the drug and the lipids of the formulations (DC1 to DC9) and DC1 formulation showed the best sustained release in 12 hr. The result of release retardant effect given by the lipids is in the order dynasan < precirol < compritol. Conclusion: The study showed that Compritol ATO 888 (glyceryl behenate) was highly hydrophobic lipid and therefore showed best sustained release of water-soluble drug theophylline as compared to Precirol ATO 5 (glyceryl palmitostearate) and Dynasan 114 (glyceryl tri myristate) lipids.

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Section: Statistical Analysis Usedmentioning

confidence: 99%

Comparison of Release Retardant Effect of Some Novel Lipids by Formulating Sustained Release Tablet of BCS Class 1 Drug

Devi¹,

Sharma²,

Sharma³

et al. 2020

IJPER

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show abstract

“…The term lipid is used here in a broader sense and includes triglycerides, partial glycerides, fatty acids, steroids, and waxes. However, it is required that matrix maintains the solid state at room temperature, and for this purpose, the selection of lipids is based on the evaluation of their polymorphic, crystallinity, miscibility, and physicochemical structure [ 11 ]. Table 2 shows the main lipids employed for the preparation of lipid nanoparticles.…”

Section: Lipid Nanoparticles As Drug Carriersmentioning

confidence: 99%

“…Lipospheres were described by Domb applying a sonication process [ 3 – 5 ]. To overcome the drawbacks associated to the traditional colloidal systems [ 6 ], such as emulsions [ 7 ], liposomes [ 8 ], and polymeric nanoparticles [ 9 ], solid lipid nanoparticles (SLN) [ 10 , 11 ] have been developed for similar purposes [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

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Current State-of-Art and New Trends on Lipid Nanoparticles (SLN and NLC) for Oral Drug Delivery

Severino

Andreani

Macedo

et al. 2012

Journal of Drug Delivery

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228

137

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Lipids and lipid nanoparticles are extensively employed as oral-delivery systems for drugs and other active ingredients. These have been exploited for many features in the field of pharmaceutical technology. Lipids usually enhance drug absorption in the gastrointestinal tract (GIT), and when formulated as nanoparticles, these molecules improve mucosal adhesion due to small particle size and increasing their GIT residence time. In addition, lipid nanoparticles may also protect the loaded drugs from chemical and enzymatic degradation and gradually release drug molecules from the lipid matrix into blood, resulting in improved therapeutic profiles compared to free drug. Therefore, due to their physiological and biodegradable properties, lipid molecules may decrease adverse side effects and chronic toxicity of the drug-delivery systems when compared to other of polymeric nature. This paper highlights the importance of lipid nanoparticles to modify the release profile and the pharmacokinetic parameters of drugs when administrated through oral route.

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“…To achieve a stable drug-loaded SLNs, in the current research, binary mixtures of span 80 (HLB: [44]. The results showed that TE-SLNs containing SA and PA are not stable.…”

Section: Optimizing Te-slnsmentioning

confidence: 88%

An investigation on parameters affecting the optimization of testosterone enanthate loaded solid nanoparticles for enhanced transdermal delivery

Tajbakhsh

Saeedi

Âkbari

et al. 2020

Colloids and Surfaces A: Physicochemical and Engineering Aspect

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Crystallinity of Dynasan®114 and Dynasan®118 matrices for the production of stable Miglyol®-loaded nanoparticles

Cited by 29 publications

References 30 publications

Comparison of Release Retardant Effect of Some Novel Lipids by Formulating Sustained Release Tablet of BCS Class 1 Drug

Comparison of Release Retardant Effect of Some Novel Lipids by Formulating Sustained Release Tablet of BCS Class 1 Drug

Current State-of-Art and New Trends on Lipid Nanoparticles (SLN and NLC) for Oral Drug Delivery

An investigation on parameters affecting the optimization of testosterone enanthate loaded solid nanoparticles for enhanced transdermal delivery

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