Crystallization Behavior and Nucleation Kinetics of Organic Melt Droplets in a Microfluidic Device

Spiegel, Burkard; Käfer, Alexander; Kind, Matthias

doi:10.1021/acs.cgd.7b01697

Cited by 13 publications

(12 citation statements)

References 47 publications

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“…[154] Measurement of the evolution of the fraction of droplets that contain crystals over time under constant supersaturation therefore yields the nucleation kinetics, [68] as discussed in Section 5.2.1. Analysis of nucleation kinetics has been carried out for a wide range of systems including proteins, [155,156] soluble organics [156,157] and inorganics, [68,70,85,158] poorly-soluble compounds, [159,160] and the solidification of melts, [161,162] and most systems exhibit complex nucleation kinetics due to multiple pathways.…”

Section: Segmented-flow Microfluidic Systemsmentioning

confidence: 99%

Crystallization in Confinement

2020

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Many crystallization processes of great importance, including frost heave, biomineralization, the synthesis of nanomaterials, and scale formation, occur in small volumes rather than bulk solution. Here, the influence of confinement on crystallization processes is described, drawing together information from fields as diverse as bioinspired mineralization, templating, pharmaceuticals, colloidal crystallization, and geochemistry. Experiments are principally conducted within confining systems that offer well‐defined environments, varying from droplets in microfluidic devices, to cylindrical pores in filtration membranes, to nanoporous glasses and carbon nanotubes. Dramatic effects are observed, including a stabilization of metastable polymorphs, a depression of freezing points, and the formation of crystals with preferred orientations, modified morphologies, and even structures not seen in bulk. Confinement is also shown to influence crystallization processes over length scales ranging from the atomic to hundreds of micrometers, and to originate from a wide range of mechanisms. The development of an enhanced understanding of the influence of confinement on crystal nucleation and growth will not only provide superior insight into crystallization processes in many real‐world environments, but will also enable this phenomenon to be used to control crystallization in applications including nanomaterial synthesis, heavy metal remediation, and the prevention of weathering.

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Section: Segmented-flow Microfluidic Systemsmentioning

confidence: 99%

Crystallization in Confinement

2020

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“…The latter has a different chemical structure than the medium to be crystallized. Plenty of work exists dealing with the influence of primary nucleation on the crystallization of emulsions [3,9,11].…”

Section: Collision-induced Nucleationmentioning

confidence: 99%

Influence of Shear Flow on the Crystallization of Organic Melt Emulsions – A Rheo‐Nuclear Magnetic Resonance Investigation

et al. 2020

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There is a need to better understand the influence of shear flow on the crystallization of a molten oil phase in an oil/water emulsion due to its high relevance for industrial processes. The present study focuses on the influence of laminar shear flow on the crystallization kinetics of polydisperse n‐hexadecane‐in‐water emulsions. The investigation was carried out by rheo‐nuclear magnetic resonance (NMR) spectroscopy in a Taylor‐Couette geometry. An accelerating impact of the shear rate on the overall crystallization kinetics was verified. This effect stems from an increase of the collision frequency of already crystallized droplets with not yet crystallized droplets. Nevertheless, the collision efficiency decreased with higher shear rate.

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“…8,9 The microfluidic technologies are therefore growing in popularity as a means of studying nucleation kinetics. [10][11][12] Most of these reported studies focus on investigating highly soluble compounds such as proteins and KNO3, where nucleation is readily induced by evaporation of water or change of temperature.…”

Section: Introductionmentioning

confidence: 99%

Investigating the Nucleation Kinetics of Calcium Carbonate Using a Zero-Water-Loss Microfluidic Chip

Zhang

Gao

Meldrum

et al. 2020

Crystal Growth & Design

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Characterization of nucleation processes is essential to the development of strategies to control crystallization in many industrial, atmospheric, biological, and geological environments. An effective route to studying nucleation processes is the use of large numbers of small, identical volumes, where these minimize the effects of impurities that can dominate in bulk solution and allow the stochastic nature of nucleation to be considered. Here, we present a multilayered microfluidic device for nucleation studies that can be used to carry out 10 000 simultaneous reactions in identical microcavities, and 500 of them are used for investigating nucleation kinetics. Unlike droplet-based systems, no surfactants are required, and the presence of an integrated water

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Crystallization Behavior and Nucleation Kinetics of Organic Melt Droplets in a Microfluidic Device

Cited by 13 publications

References 47 publications

Crystallization in Confinement

Crystallization in Confinement

Influence of Shear Flow on the Crystallization of Organic Melt Emulsions – A Rheo‐Nuclear Magnetic Resonance Investigation

Investigating the Nucleation Kinetics of Calcium Carbonate Using a Zero-Water-Loss Microfluidic Chip

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