Crystallization, Bulk, Macromolecules

Rosa, Ana; McPherson, Alexander

doi:10.1002/0471250589.ebt062

Cited by 1 publication

(1 citation statement)

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“…Variations of this venerable process (Chang, 1988;McIntosh et al, 1994;Stryker et al, 1985) are still being used, in particular for human serum albumin, which can be heat sterilized. Applications of crystallization in modern biotechnology (Becker and Lawlis, 1991;Becker et al, 1997;de la Rosa and McPherson, 1999;Harrison et al, 2003, Ch. 8;Heng, 2003aHeng, , 2003bJohns, 1999; are increasingly important.…”

Section: Final Purificationmentioning

confidence: 99%

Bioseparations

Lightfoot

Moscariello

2004

Biotech & Bioengineering

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Here we review key applications of separation technology in applied biology. We first sketch out the field as a whole, but then narrow our scope to the processing of fermentation products, particularly to high-value biologicals such as proteins and nucleotides. We go on to provide a qualitative overview describing the importance and general nature of this large field, major trends, and the strategies that have proven most fruitful in evolving effective separation and purification processes. We then give a detailed description of individual separations equipment and the principles governing their operation. We concentrate throughout on making the available literature accessible to the reader; we provide what is hoped to be a representative set of basic references. However, these references, in turn, include some that suggest promising new developments as well as a number of more specialized reviews. We hope that our overall result provides the reader with access to the most relevant literature. B

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Section: Final Purificationmentioning

confidence: 99%