Crystallization of an Aromatic Biopolyester

Hany, Roland; Brinkmann, Martin; Ferri, Davide; Hartmann, René; Pletscher, E.; Rentsch, Daniel; Zinn, Manfred

doi:10.1021/ma900995w

Cited by 11 publications

(9 citation statements)

References 31 publications

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“…It was observed that increasing aromatic fraction results in a linear increase of the polymer's T g from −37.6 • C to −6 • C [131]. Later, DNL cultivation in a single-stage chemostat was carried out with mixtures of lactic acid and the aromatic compounds p-methylphenylvaleric acid or phenylvaleric acid [132]. In the case of using p-methylphenylvaleric acid as co-substrate, a poly(3-hydroxy-p-methylphenylvalerate) mcl-PHA homopolyester was obtained, which displayed considerable crystallinity and a sharp T m at 99 • C, which is in contrast to others described, often completely amorphous mcl-PHA biopolyesters.…”

Section: Dual Nutrient Limited Chemostat Cultivation To Utilize "Inefmentioning

confidence: 99%

“…Poly(3-hydroxy-phenylvalerate), the homopolyester produced by using phenylvaleric acid as co-substrate, displayed material properties typical for mcl-PHA. Again, the authors underlined that chemostat cultivation, especially using DNL regime, is the only possibility to culture PHA producing microbes on such "inefficient" substrates like described aromatic compounds, which exert considerable toxicity to the cells [132].…”

Section: Dual Nutrient Limited Chemostat Cultivation To Utilize "Inefmentioning

confidence: 99%

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A Review on Established and Emerging Fermentation Schemes for Microbial Production of Polyhydroxyalkanoate (PHA) Biopolyesters

Koller

2018

Fermentation

152

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Polyhydroxyalkanoates (PHA) are microbial biopolyesters utilized as "green plastics". Their production under controlled conditions resorts to bioreactors operated in different modes. Because PHA biosynthesis constitutes a multiphase process, both feeding strategy and bioreactor operation mode need smart adaptation. Traditional PHA production setups based on batch, repeated batch, fed-batch or cyclic fed-batch processes are often limited in productivity, or display insufficient controllability of polyester composition. For highly diluted substrate streams like is the case of (agro) industrial waste streams, fed-batch enhanced by cell recycling has recently been reported as a viable tool to increase volumetric productivity. As an emerging trend, continuous fermentation processes in single-, two-and multi-stage setups are reported, which bring the kinetics of both microbial growth and PHA accumulation into agreement with process engineering and allow tailoring PHA's molecular structure. Moreover, we currently witness an increasing number of CO 2-based PHA production processes using cyanobacteria; these light-driven processes resort to photobioreactors similar to those used for microalgae cultivation and can be operated both discontinuously and continuously. This development is parallel to the emerging use of methane and syngas as abundantly available gaseous substrates, which also calls for bioreactor systems with optimized gas transfer. The review sheds light on the challenges of diverse PHA production processes in different bioreactor types and operational regimes using miscellaneous microbial production strains such as extremophilic Archaea, chemoheterotrophic eubacteria and phototrophic cyanobacteria. Particular emphasis is dedicated to the limitations and promises of different bioreactor-strain combinations and to efforts devoted to upscaling these processes to industrially relevant scales.

show abstract

Section: Dual Nutrient Limited Chemostat Cultivation To Utilize "Inefmentioning

confidence: 99%

Section: Dual Nutrient Limited Chemostat Cultivation To Utilize "Inefmentioning

confidence: 99%

A Review on Established and Emerging Fermentation Schemes for Microbial Production of Polyhydroxyalkanoate (PHA) Biopolyesters

Koller

2018

Fermentation

152

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show abstract

“…It should be emphasized that chemostat cultivation processes, especially using DNL substrate supply, might be the only efficient strategy to thrive PHA producing strains on toxic substrates like the described aromatic compounds. 97 Long chain length PHA (lcl-PHA)…”

Section: Dual Nutrient Limited Cultivation To Produce Mcl-pha Of Tailmentioning

confidence: 99%

Chemical and Biochemical Engineering Approaches in Manufacturing Polyhydroxyalkanoate (PHA) Biopolyesters of Tailored Structure with Focus on the Diversity of Building Blocks

Koller¹

2019

Chem.Biochem.Eng.Q.

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Polyhydroxyalkanoates (PHA) constitute prokaryotic storage materials not only harnessing microbial cells with benefits for survival under challenging environmental conditions, but also attracting attention as biological materials with properties resembling those of currently used thermoplasts and elastomers of petrochemical origin. Strongly dependent on their monomeric composition and microstructure, PHA´s exact material properties are predestined in statu nascendi, hence, during their biosynthesis. The present review sheds light on established and emerging strategies to produce differently composed PHA homo-, co-, ter-, and quarterpolyesters from the groups of short-, medium-, and long-chain PHA. It is shown how microbial strain selection, sophisticated genetic strain engineering based on synthetic biology approaches, advanced feeding strategies, and smart process engineering can be implemented to generate PHA of tailored monomeric composition, microstructure, molar mass, and molar mass distribution. Tailoring these parameters offers the possibility to produce customer-oriented PHA for various purposes, such as packaging materials, carriers of pharmaceutically active compounds, implants, or other emerging fields of use.

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“…Poly(3hydroxy-phenylvalerate), the homopolyester produced by using phenylvaleric acid as co-substrate, displayed material properties typical for mcl-PHA. Again, the authors underlined that chemostat cultivation, especially using DNL regime, is the only possibility to culture PHA producing microbes on such "inefficient" substrates like described aromatic compounds, which exert considerable toxicity to the cells [128].…”

Section: Generalmentioning

confidence: 99%

A Review on Established and Emerging Fermentation Schemes for Microbial Production of Polyhydroxyalkanoate (PHA) Biopolyesters

Koller¹

2018

Preprint

View full text Add to dashboard Cite

Polyhydroxyalkanoates (PHA) are microbial biopolyesters utilized as “green plastics”. Their production under controlled conditions resorts to bioreactors operated in different modes. Because PHA biosynthesis constitutes a multiphase process, both feeding strategy and bioreactor operation mode need smart adaptation. Traditional PHA production setups based on batch, repeated batch, fed-batch or cyclic fed-batch processes are often limited in productivity, or display insufficient controllability of polyester composition. For highly diluted substrate streams like it is the case for (agro)industrial waste streams, fed-batch enhanced by cell recycling were recently reported as a viable tool to increase volumetric productivity. As emerging trend, continuous fermentation processes in single-, two-, and multi-stage setups are reported, which bring the kinetics of both microbial growth and PHA accumulation into agreement with process engineering, and allow tailoring PHA´s molecular structure. Moreover, we currently witness an increasing number of CO2-based PHA production processes using cyanobacteria; these light-driven processes resort to photobioreactors similar to those used for microalgae cultivation, and can be operated both discontinuously and continuously. This development goes in parallel to the emerging use of methane and syngas as an abundantly available gaseous substrates, which also calls for bioreactor systems with optimized gas transfer. The review sheds light on the challenges of diverse PHA production processes in different bioreactor types and operational regimes using miscellaneous microbial production strains such as extremophilic Archaea, chemoheterotrophic eubacteria and phototrophic cyanobacteria. Particular emphasize is dedicated to the limitations and promises of different bioreactor-strain combinations, and to efforts devoted to upscaling these processes to industrially relevant scales.

show abstract

Crystallization of an Aromatic Biopolyester

Cited by 11 publications

References 31 publications

A Review on Established and Emerging Fermentation Schemes for Microbial Production of Polyhydroxyalkanoate (PHA) Biopolyesters

A Review on Established and Emerging Fermentation Schemes for Microbial Production of Polyhydroxyalkanoate (PHA) Biopolyesters

Chemical and Biochemical Engineering Approaches in Manufacturing Polyhydroxyalkanoate (PHA) Biopolyesters of Tailored Structure with Focus on the Diversity of Building Blocks

A Review on Established and Emerging Fermentation Schemes for Microbial Production of Polyhydroxyalkanoate (PHA) Biopolyesters

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