Crystallization of the polymorphs of succinic acid via sublimation at different temperatures in the presence or absence of water and isopropanol vapor

Yu, Qiushuo; Dang, Leping; Black, Simon; Wei, Hongyuan

doi:10.1016/j.jcrysgro.2011.12.050

Cited by 31 publications

(44 citation statements)

References 21 publications

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“…As shown in Fig. 1, the pure components used in this study were CBZ Form III [17], α polymorph of FUM [25] and β polymorph of SA [26].…”

Section: A Powder X-ray Diffraction (Pxrd)mentioning

confidence: 99%

“…Based on the patterns, diffraction peaks for CBZ-SA in all solvent matched with previous studied conducted by other scholars by ±10% deviation [23], [30], [31] and does not contain any diffraction peaks of pure components of CBZ and SA which confirms that the powder sample measured was a co-crystal except for formic acid. There were some pattern peaks found in formic acid solvent system that similar to succinic anhydride [26] and CBZ-formic acid solvate [32], therefore it was suspected that there were mixture of both components in the solvent system. However, there is significant different between patterns produced using non-stoichiometric and stoichiometric methods.…”

Section: A Powder X-ray Diffraction (Pxrd)mentioning

confidence: 99%

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Carbamazepine-Fumaric Acid and Carbamazepine-Succinic Acid Co-crystal Screening Using Solution Based Method

Rahman¹,

Rahim²,

Chou³

et al. 2017

IJCEA

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Abstract-Co-crystal plays a critical role in the pharmaceutical industry and becoming as an alternative approach to improve the bioavailability of poor water soluble drugs especially for a weakly ionisable groups or neutral compounds. In this study the co-crystal screening was carried out for carbamazepine (CBZ) and co-crystal former (CCF) of fumaric acid (FUM) and succinic acid (SA) using non-stoichiometric method (addition of CBZ to CCF saturated solution) and stoichiometric method (evaporation of 1:1 molar ratio of CBZ to CCF) in acetonitrile, ethyl acetate, propanol, ethanol and formic acid solvent systems. The crystals produced from the screening were characterized using Powder X-ray Diffraction (PXRD), Differential Scanning Calorimetry (DSC) and Fourier Transform Infrared (FT-IR). The PXRD analysis had confirmed that the co-crystal was successfully formed in both methods for all of the solvent system studied with an exception to formic acid in the stoichiometric method for CBZ-FUM system and in all methods for CBZ-SA system. The findings from this analysis revealed that Form A and Form B of CBZ-FUM co-crystal had been successfully formed from different solvents systems. DSC analysis had shown that the melting point of CBZ-FUM and CBZ-SA co-crystals were in the range similar to the previous study. The characterization using FT-IR indicated that the functional groups which include amides and carboxylic acids were presented in the co-crystal produced. Further study on the co-crystal solubility and dissolution rate is needed in order to access the efficacy of the co-crystal since the screening methods have been successfully confirmed the formation of the co-crystal.

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“…As shown in Fig. 1, the pure components used in this study were CBZ Form III [17], α polymorph of FUM [25] and β polymorph of SA [26].…”

Section: A Powder X-ray Diffraction (Pxrd)mentioning

confidence: 99%

Section: A Powder X-ray Diffraction (Pxrd)mentioning

confidence: 99%

Carbamazepine-Fumaric Acid and Carbamazepine-Succinic Acid Co-crystal Screening Using Solution Based Method

Rahman¹,

Rahim²,

Chou³

et al. 2017

IJCEA

View full text Add to dashboard Cite

show abstract

“…Crystals with higher high shape factor exhibited high sedimentation volume and easy redispersibility. It was proposed that Reproduced with permission from [25].…”

Section: Solventmentioning

confidence: 99%

“…Evaluation of ratio of α:β polymorphic forms (Ri) in the resultant crystals revealed that in presence of water, Ri increased manifolds with increase in supersaturation, whereas, isopropanol required a very high supersaturation to obtain a greater Ri value, indicating that water favored α-form and isopropanol favored the stable β-form ( Figure 4) [25].…”

Section: 80 195mentioning

confidence: 99%

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Understanding Pharmaceutical Polymorphic Transformations II: Crystallization Variables and Influence on Dosage Forms

et al. 2015

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Excipients or formulation variables have often been exploited to improve stability, modify release, or improve physicochemical properties of dosage forms. In pharmaceutical field, it is generally expected that excipients work at macromolecular level where they might influence the crystal structure of a solid. These polymers/colloidal particles may modify the rate and direction of crystal growth. It has also been observed, that different polymorphic crystals exhibit different colors on exposure to same colorant, predominantly due to difference in surface pH of different crystal lattices. Apart from physicochemical affect, crystal habit also influences pharmacokinetic parameters of the dosage form. Crystals with smaller size or lower lattice energy have shown to exhibit higher bioavailability with faster rate of release.

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Crystallization and Purification of 4,4′‐Diaminodiphenyl Ether

Chen

Han

et al. 2020

Chem Eng & Technol

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The purification of 4,4 -diaminodiphenyl ether (ODA) was investigated. ODA, which contained impurities, was sublimated and anti-solvent (ethanol)-crystallized in N-dimethylformamide (DMF). Fourier transform infrared (FTIR) results revealed that the sublimated crystal was basically identical with the pure ODA sample. The influence of different amounts of ethanol on particle size distribution was analyzed during anti-solvent crystallization. The morphology of the ODA crystal was examined by scanning electron microscopy (SEM). The color of the sample enhanced from a brown powder to a colorless granular crystal. The purity of the sample could be increased from about 30 % to 87 %. With the operations of sublimation and anti-solvent crystallization, the purity, crystal morphology, and particle size distribution of ODA were significantly improved.

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Crystallization of the polymorphs of succinic acid via sublimation at different temperatures in the presence or absence of water and isopropanol vapor

Cited by 31 publications

References 21 publications

Carbamazepine-Fumaric Acid and Carbamazepine-Succinic Acid Co-crystal Screening Using Solution Based Method

Carbamazepine-Fumaric Acid and Carbamazepine-Succinic Acid Co-crystal Screening Using Solution Based Method

Understanding Pharmaceutical Polymorphic Transformations II: Crystallization Variables and Influence on Dosage Forms

Crystallization and Purification of 4,4′‐Diaminodiphenyl Ether

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