CRYSTALLIZATION—PART I. ANNUAL REVIEW - "Transport Phenomena of Nucleation and Crystal Growth"

Botsaris, Gregory D.; Denk, Edward G.; Ersan, Gun S.; Kirwan, Donald J.; Margolis, Geoffrey.; Ohara, Makoto.; Reid, Robert C.; Tester, Jefferson W.

doi:10.1021/ie50718a009

Cited by 8 publications

(3 citation statements)

References 16 publications

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“…Random collisions among the nucleating centers in aqueous phase facilitate the nonpolar interactions among the hydrophobic domains of capped zein. This promotes the interparticle fusion among the growing nucleating centers, 30 and hence, several small nucleating centers merge into a single NP resulting in a blue shift of ∼10 nm. A variation in the blue shift for reactions with different amounts of gold salt is depicted in Figure 1d.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

Green Chemistry of Zein Protein Toward the Synthesis of Bioconjugated Nanoparticles: Understanding Unfolding, Fusogenic Behavior, and Hemolysis

Mahal

Khullar²,

Kumar

et al. 2013

ACS Sustainable Chem. Eng.

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Green chemistry of industrially important zein protein was explored in aqueous phase toward the synthesis of bioconjugated gold (Au) nanoparticles (NPs), which allowed us to simultaneously understand the unfolding behavior of zein with respect to temperature and time. Synthesis of Au NPs was monitored with simultaneous measurements of UV–visible absorbance due to the surface plasmon resonance (SPR) of Au NPs that triggered the adsorption of zein on the NP surface and thus resulted in its unfolding. Surface adsorption of zein further controlled the crystal growth of Au NPs, which relied on the degree of unfolding and fusogenic behavior of zein due to its predominant hydrophobic nature. The latter property induced a marked blue shift in the SPR rarely observed in the growing NPs during the nucleation process. A greater unfolding of zein in fact was instrumental in generating zein-coated faceted NPs that were subjected to their hemolytic response for their possible use as drug release vehicles. Zein coating significantly reduced the hemolysis and made bioconjugated Au NPs the best models for biomedical applications in nanotechnology.

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Section: ■ Results and Discussionmentioning

confidence: 99%

Green Chemistry of Zein Protein Toward the Synthesis of Bioconjugated Nanoparticles: Understanding Unfolding, Fusogenic Behavior, and Hemolysis

Mahal

Khullar²,

Kumar

et al. 2013

ACS Sustainable Chem. Eng.

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“…Notice that the process rate also depends linearly on the degree of agitation α as proposed in ref. 23 with α ≥ 0. The value of α accounts for the magnitude of shear rates in the system, but it does not account for the stirring modes.…”

Section: Emergence Of Enantiomeric Structuresmentioning

confidence: 99%

Variations in activation energy and nuclei size during nucleation explain chiral symmetry breaking

Arango-Restrepo,

Barragán,

Rubi

2023

Phys. Chem. Chem. Phys.

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“…A number of excellent books and monographs that present the state-of-the-art in this rapidly moving field have been published since 1960. Reviews by Botsaris et al (1969) provide quick reference material for many contemporary phases of the subject. Publications by Mullin (196l), Van Hook (l961), and Strickland-Constable (1968) consolidate much of the background material in crystallization fundamentals.…”

Section: Introductionmentioning

confidence: 99%

Crystal‐size distribution and its interaction with crystallizer design

Moyers¹,

Randolph

1973

AIChE Journal

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Recent progress in understanding crystallization processes is reviewed, especially with regard to the problem of crystal-size distribution (CSD) and its many interactions with the design, analysis, and operation of crystallizers. This subject is considered from both the researcher's and practitioner's points of view, and special attention is given to the impact of recent theories on crystallizer design and operation.A generalized theory for the analysis and prediction of CSD, based on population balance mechanics, has been developed and tested over the past decade. Predictive design of CSD is now a possibility with the design techniques presented here and using suitable bench-scale data. Published evaluations of the reliability of design methods utilized in commercial practice would be a valuable asset to the science of crystallization. CHARLES G. MOYERS, JR. Engineering SCOPEMuch work has been done on the problem of crystalsize distribution (CSD) and its relation to crystallizer design and operation. An especially rapid burst of activity in this area has occurred over the last decade. Analytical studies of CSD both reveal the need and provide the means for quantitative measurement of secondary nucleation in realistic well-mixed crystallizers. The population balance theory of CSD provides the unifying link between predictive CSD studies in complex crystallizer configurations and descriptions of crystal growth and nucleation kinetics. Development has proceeded rapidly in both of these areas over the last few years, with each area reinforcing and motivating work in the other.A mass-based theory rather than population-based theory of crystallizer analysis has emerged from recent work in Europe. Experiments have been developed that yield kinetic information that potentially could be used in either mass-based or population-based crystal-size distribution algorithms. The implications and limitations of these theories are discussed in the text. The purpose of this review is to outline the advances that have been made in the analysis of crystal-size distribution and crystallization kinetics with particular emphasis on how these studies might influence the design and operation of industrial systems. Mention is made of areas that have received inadequate attention and/or areas where further studies seem appropriate. CONCLUSIONS AND SIGNIFICANCEStudy of crystallization kinetics and related crystalsize distribution (CSD) has increased understanding of the complex interactions that occur in crystallizers and has opened up new vistas of exploration in crystallization technology. Continued feedback by users of the various analytical modeling techniques and persistent investigation of interphase kinetics are needed to strengthen the underlying knowledge of crystallization technology.The design and analysis of crystallization processes of the continuous well-mixed suspension type have developed into formal design algorithms which can now be applied in situations of industrial importance. Specific process configurations that can ...

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CRYSTALLIZATION—PART I. ANNUAL REVIEW - "Transport Phenomena of Nucleation and Crystal Growth"

Cited by 8 publications

References 16 publications

Green Chemistry of Zein Protein Toward the Synthesis of Bioconjugated Nanoparticles: Understanding Unfolding, Fusogenic Behavior, and Hemolysis

Green Chemistry of Zein Protein Toward the Synthesis of Bioconjugated Nanoparticles: Understanding Unfolding, Fusogenic Behavior, and Hemolysis

Variations in activation energy and nuclei size during nucleation explain chiral symmetry breaking

Crystal‐size distribution and its interaction with crystallizer design

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