Crystallization tendency and polymorphic transitions in triglyceride nanoparticles

Bunjes, Heike; Westesen, Kirsten; Koch, Michel H. J.

doi:10.1016/0378-5173(95)04286-5

Cited by 382 publications

(253 citation statements)

References 13 publications

Supporting

Mentioning

237

Contrasting

Unclassified

Order By: Relevance

“…As suggested in the literature, the presence of surfactants and the interaction of solid lipid with the liquid lipid could also be responsible for the depression of Bunjes et al (1996), Jenning et al (2000) and Zimmermann et al (2005). Table 2 shows that the enthalpy and CI of NLC was lower than that of the SLN and CP and the depression of CI became more pronounced in NLC with higher content of the CA.…”

Section: Differential Scanning Calorimetrymentioning

confidence: 94%

Development of nanostructured lipid carriers for controlled delivery of mefenamic acid

Khurana

Bedi

Jain

2012

IJBNN

View full text Add to dashboard Cite

This study was aimed to develop nanostructured lipid carriers (NLC) for the possible delivery of mefenamic acid. This study describes the effect of liquid lipid concentration on the characteristics of NLC such as particle size, polydispersity index, zeta potential, drug entrapment efficiency, and occlusivity index. Transmission electron microscopy revealed nearly spherical shape NLC with negligible effect of liquid lipid content on the particle morphology. The differential scanning calorimetry demonstrated a depression in the melting point and crystallinity index of the NLC with an increase in the amount of liquid lipid. The in vitro drug release studies demonstrated that solid lipid nanoparticle (0% oil), and NLC possessed a biphasic release pattern characterised by a rapid initial release followed by a sustained release, in comparison to nanoemulsions (100% oil) of which a nearly constant release was observed. Compared to NE and SLN, the excellent physical stability of NLC against drug leakage was seen.

show abstract

Section: Differential Scanning Calorimetrymentioning

confidence: 94%

Development of nanostructured lipid carriers for controlled delivery of mefenamic acid

Khurana

Bedi

Jain

2012

IJBNN

View full text Add to dashboard Cite

show abstract

“…Supercooling of SLNs is also an important feature to be ensured after melt homogenization, otherwise the final product would appear as a nanoemulsion rather than colloidally dispersed SLNs (Bunjes et al, 1996). Moreover, the solid matrix is expected to remain in the solid state at body temperatures so that controlled and sustained drug release properties could be achieved (Bunjes et al, 1996).…”

Section: Lipidsmentioning

confidence: 99%

Solid lipid nanoparticles for ocular drug delivery

2010

View full text Add to dashboard Cite

“…X-ray diffraction has been used for the study of molecular structure and polymorphism of lipid nanoparticles [17,18]. Therefore, these measurements were performed after 7 days of storage at room temperature, in order to compare the crystalline nature of the investigated lipid particles.…”

Section: X-ray Diffractionmentioning

confidence: 99%

Evaluation of the physical stability of SLN and NLC before and after incorporation into hydrogel formulations

Souto

Wissing

Barbosa

et al. 2004

European Journal of Pharmaceutics and Biopharmaceutics

201

View full text Add to dashboard Cite

Aqueous dispersions of lipid nanoparticles are being investigated as drug delivery systems for different therapeutic purposes. One of their interesting features is the possibility of topical use, for which these systems have to be incorporated into commonly used dermal carriers, such as creams or hydrogels, in order to have a proper semisolid consistency. For the present investigation four different gel-forming agents (xanthan gum, hydroxyethylcellulose 4000, Carbopol w 943 and chitosan) were selected for hydrogel preparation. Aqueous dispersions of lipid nanoparticles-solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC)-made from tripalmitin were prepared by hot high pressure homogenization and then incorporated into the freshly prepared hydrogels. NLC differ from SLN due to the presence of a liquid lipid (Miglyol w 812) in the lipid matrix. Lipid nanoparticles were physically characterized before and after their incorporation into hydrogels. By means of rheological investigations it could be demonstrated that physical properties of the dispersed lipid phase have a great impact on the rheological properties of the prepared semisolid formulations. By employing an oscillation frequency sweep test, significant differences in elastic response of SLN and NLC aqueous dispersions could be observed. q

show abstract

Crystallization tendency and polymorphic transitions in triglyceride nanoparticles

Cited by 382 publications

References 13 publications

Development of nanostructured lipid carriers for controlled delivery of mefenamic acid

Development of nanostructured lipid carriers for controlled delivery of mefenamic acid

Solid lipid nanoparticles for ocular drug delivery

Evaluation of the physical stability of SLN and NLC before and after incorporation into hydrogel formulations

Contact Info

Product

Resources

About