We study the existence of post-Lie algebra structures on pairs of Lie algebras
, where one of the algebras is perfect non-semisimple, and the other one is abelian, nilpotent non-abelian, solvable non-nilpotent, simple, semisimple non-simple, reductive non-semisimple or complete non-perfect. We prove several nonexistence results, but also provide examples in some cases for the existence of a post-Lie algebra structure. Among other results we show that there is no post-Lie algebra structure on
, where
is perfect non-semisimple, and
is
. We also show that there is no post-Lie algebra structure on
, where
is perfect and
is reductive with a 1-dimensional center.