DOI: 10.17077/etd.sewc-5bd7
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Crystallographic and spectroscopic assessment of pharmaceutical material mechanics

Abstract: AbbVie for the opportunity to intern in the Manufacturing Science & Technology group and giving me the chance to gain insights into drug product design. I would also like to acknowledge Dr. Yihong Qiu at AbbVie for his continued mentorship and help during my search for employment. I am extremely grateful to all the faculty and staff members of the Division of Pharmaceutics and Translational Therapeutics, College of Pharmacy, for their valuable support during the graduate study. I thank Dr. Keith Guillory, Drs.… Show more

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Cited by 1 publication
(3 citation statements)
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“…Elasticity has been used to probe the interaction strength of materials through the calculation of elastic constants. These elastic constants can either be obtained through a variety of different experimental techniques using single crystals. , The engineering moduli (e.g., bulk ( K ), shear ( G ), longitudinal ( M ), and Young’s modulus ( E )) for polycrystalline solids can be calculated from the elastic constants using common averaging techniques like the Reuss or Voigt method. , Alternately computational methods can be employed to obtain elastic tensors and relevant mechanical properties. , In addition to the mechanical properties, the tensors can be used to calculate the degree of anisotropy and to construct sound velocity polar plots to graphically represent the interaction topology. Karki et al calculated the compliance tensors (inverse of the elastic constants tensor) for paracetamol and its cocrystals to interpret their respective tableting performance .…”
Section: Introductionmentioning
confidence: 99%
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“…Elasticity has been used to probe the interaction strength of materials through the calculation of elastic constants. These elastic constants can either be obtained through a variety of different experimental techniques using single crystals. , The engineering moduli (e.g., bulk ( K ), shear ( G ), longitudinal ( M ), and Young’s modulus ( E )) for polycrystalline solids can be calculated from the elastic constants using common averaging techniques like the Reuss or Voigt method. , Alternately computational methods can be employed to obtain elastic tensors and relevant mechanical properties. , In addition to the mechanical properties, the tensors can be used to calculate the degree of anisotropy and to construct sound velocity polar plots to graphically represent the interaction topology. Karki et al calculated the compliance tensors (inverse of the elastic constants tensor) for paracetamol and its cocrystals to interpret their respective tableting performance .…”
Section: Introductionmentioning
confidence: 99%
“…26,27 The engineering moduli (e.g., bulk (K), shear (G), longitudinal (M), and Young's modulus (E)) for polycrystalline solids can be calculated from the elastic constants using common averaging techniques like the Reuss or Voigt method. 28,29 Alternately computational methods can be employed to obtain elastic tensors and relevant mechanical properties. 28,30−32 In addition to the mechanical properties, the tensors can be used to calculate the degree of anisotropy and to construct sound velocity polar plots to graphically represent the interaction topology.…”
Section: Introductionmentioning
confidence: 99%
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