Crystallographic, antibacterial, and in silico studies of Ni(II) and Cu(II) Schiff base complexes derived from 2-acetylpyridine

Mohd Alwi, Nur Syafiqah; Hamali, Muhamad Azwan; Rosnizam, Arif Naim; Muhammad Low, Anis Low; El Hassane, Anouar; A. Nassar, Amal; Mohd Tajuddin, Amalina

doi:10.1016/j.ica.2023.121742

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

Publication Types

Select...

Article3

Preprint2

Relationship

Self Cite0

Independent5

Authors

Journals

Cited by 5 publications

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Cu(II) complexes based on benzimidazole ligands: synthesis, characterization, DFT, molecular docking & bioactivity study

Hamali,

Roney,

Dubey

et al. 2024

Future Medicinal Chemistry

View full text Add to dashboard Cite

Cu(II) complexes based on benzimidazole ligands: synthesis, characterization, DFT, molecular docking & bioactivity study

Hamali,

Roney,

Dubey

et al. 2024

Future Medicinal Chemistry

View full text Add to dashboard Cite

Studies on some Anthranilic acid based mixed ligand Metal(II) complexes: Synthesis, characterization, in-vitro biological evaluation, ADMET profiling, DFT and molecular docking

Dhanaraj

2024

Preprint

View full text Add to dashboard Cite

Schiff base ligand L has been synthesized using 4-amino antipyrine, Furfuraldehyde, and 2-aminothiazole. This ligand, along with anthranilic acid (AA) and Metal(II) acetates of Co(II), Ni(II), Cu(II), and Zn(II) was used to produce mixed ligand complexes. Characterization of the synthesized compounds was conducted using various analytical and spectral methods including molar conductance, CHN analysis, FTIR, UV-Vis., 1H NMR, mass,ESR, and XRD. In Vitro,assessments were performed on L and its mixed ligand complexes with AA against several bacterial strains such as P. aeruginosa, E. coli, and S. aureus, together with two fungal species, A. niger and C. albicans. Additionally, the compounds were evaluated for their DNA cleavage and antioxidant potency. The results indicated that [CuL(AA)] exhibits higher biological activity compared to the other metal(II) complexes and L. Furthermore, the biological efficacy of L and its mixed ligand complexes with AA was evaluated using computational techniques, such as DFT as well as pharmacokinetic studies. Both the ligand and metal complexes exhibited notable potency, suggesting their potential as therapeutic agents for the treatment of deformities caused by pathogens.

show abstract

Cu(Ii) Complexes Based on 2-Aminomethylbenzimidazole Schiff Base Ligands: Synthesis, Structural Characterization, Dft,Molecular Docking and Bioactivity Studies

HAMALI,

Roney,

Amit

et al. 2024

Preprint

View full text Add to dashboard Cite

Crystallographic, antibacterial, and in silico studies of Ni(II) and Cu(II) Schiff base complexes derived from 2-acetylpyridine

Cited by 5 publications

References 40 publications

Cu(II) complexes based on benzimidazole ligands: synthesis, characterization, DFT, molecular docking & bioactivity study

Cu(II) complexes based on benzimidazole ligands: synthesis, characterization, DFT, molecular docking & bioactivity study

Studies on some Anthranilic acid based mixed ligand Metal(II) complexes: Synthesis, characterization, in-vitro biological evaluation, ADMET profiling, DFT and molecular docking

Cu(Ii) Complexes Based on 2-Aminomethylbenzimidazole Schiff Base Ligands: Synthesis, Structural Characterization, Dft,Molecular Docking and Bioactivity Studies

Contact Info

Product

Resources

About