Crystallographic study of rhinoliths

Abdel-Latif, Salem M.; Abdel-Hady, S.A.; Moustafa, Hassan M.

doi:10.1017/s0022215100088307

Cited by 14 publications

(5 citation statements)

References 7 publications

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“…The term rhinolith was first coined in 1845 to describe a partially or completely encrusted foreign body in the nose [11]. Calcified incrustations in the nasal cavity were subjected to a chemical analysis, first by Axmann in 1829 [12], and thereafter by various other authors [2, 11, 13–17]. In general they comprise 90% inorganic material, with the remaining 10% being made up of organic substances incorporated into the lesion from nasal secretions.…”

Section: Discussionmentioning

confidence: 99%

The Rhinolith—A Possible Differential Diagnosis of a Unilateral Nasal Obstruction

Brehmer

Riemann

2010

Case Reports in Medicine

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Rhinoliths are mineralised foreign bodies in the nasal cavity that are a chance finding at anterior rhinoscopy. Undiscovered, they grow appreciably in size and can cause a foul-smelling nasal discharge and breathing problems. Giant nasal stones are now a very rare occurrence, since improved diagnostic techniques, such as endoscopic/microscopic rhinoscopy, now make it possible to identify foreign bodies at an early stage of development. We report the case of a 37-year-old patient who, at the age of 5-6 years, introduced a foreign body, probably a stone, into his right nasal cavity. On presentation, he complained of difficulty in breathing through the right nostril that had persisted for the last 10 years. For the past four years a strong fetid smell from the nose had been apparent to those in his vicinity. Under general anaesthesia, the stone was removed in toto from the right nasal cavity. The possible genesis of the rhinolith is discussed, our case compared with those described in the literature, and possible differential diagnoses are considered.

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Section: Discussionmentioning

confidence: 99%

The Rhinolith—A Possible Differential Diagnosis of a Unilateral Nasal Obstruction

Brehmer

Riemann

2010

Case Reports in Medicine

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“…Research in the field of nonlinear optics has increasingly concentrated on the design of new organometallic complexes, since the report in 1987 by Green et al, 7 in which good second‐harmonic generation (SHG) efficiency was revealed for a ferrocenyl derivative. In recent times, organometallic complexes are among the most frequently investigated materials for their nonlinear optical properties 8–14 . The optoelectronic characteristics of these materials are extremely dependent on the d electron configuration and energy levels, which can be easily modulated through the choose of metal ion and oxidation state as well as the ligand environments.…”

Section: Introductionmentioning

confidence: 99%

Experimental and theoretical approaches on structural, spectroscopic (FT‐IR and UV‐Vis), nonlinear optical, and molecular docking analyses for Zn (II) and Cu (II) complexes of 6‐chloropyridine‐2‐carboxylic acid

Dege

Tamer

Şimşek

et al. 2022

Applied Organom Chemis

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Novel transition metal-based complexes that may be of value as biological agents and/or nonlinear optical materials, Zn (II) and Cu (II) transition metal complexes of 6-chloropyridine-2-carboxylic acid (LH), were successfully synthesized. The chemical structure of each complex was characterized using Xray diffraction (XRD) method and FT-IR spectroscopy. XRD and FT-IR demonstrated that L ligand coordinate to central metal ions through the donor N and O atoms. By coordinating two H 2 O ligand to Zn (II) ion, a distorted octahedral complex geometry was constructed for 1. As for 2, a distorted trigonal bipyramidal coordination geometry was obtained by a H 2 O ligand coordination to Cu (II) ion. Theoretical studies using B3LYP/6-311++G(d,p)-LanL2DZ were performed to further validate the proposed structures. The molecular docking of 1 to SARS-CoV-2 main protease (PDB: 6LU7) gives a binding energy of À5.24 kcal/mol and inhibition constant of 144.6 μM, demonstrating that 1 is a more promising candidate to biologically active complexes than 2. The firstorder hyperpolarizability (β) parameter for 1 and 2 was calculated as 0.88 Â 10 À30 and 10.40 Â 10 À30 esu, respectively. These β values also demonstrated that 2 exhibits more effective NLO character than 1 due to the electronic configuration and coordination geometry.

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“…The global reactivity parameters have been listed in Table 10. The global reactivity parameters are the functions of the energy of FMO (E HOMO and E LUMO ) of the ligand/the complex 37–39 . The ground state energy of the synthesized complex Me 2 SnL (4) /Me 2 Sn(SCM) (Complex 4) is lower than its corresponding ligand L (4) H 2 /SCM.…”

Section: Resultsmentioning

confidence: 99%

De novo unified robust antidiabetic pharmacophores based on biopotent hybrid material: DFT‐assisted design, optimized molecular structure, and understanding mechanism of antidiabetic bioassay

Kumawat,

Soni,

Saxena

et al. 2023

Applied Organom Chemis

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De novo unified robust antidiabetic pharmacophores based on hybrid material were rationally designed, generated, and characterized by spectroscopic evidences and DFT (B3LYP method). These hybrid pharmacophores demonstrated robust antidiabetic activity. Semicarbazones were used for the generation of these hybrid pharmacophores. Semicarbazones of heterocyclic β‐diketones were synthesized by conventional heating as well by green approach (microwave heating). The results obtained from both the approaches have been summarized and compared. Incorporation of dimethyltin(IV) moiety into some semicarbazones of heterocyclic β‐diketones resulted in the formation of biopotent dimethyltin(IV) formulations of the type Me2SnLA where LH2 = , R = −CH3, L(1)H2, Complex 1; R = −CH2CH3, L(2)H2, Complex 2; R = −C6H5, L(3)H2, Complex 3; and R = p‐ClC6H4−, L(4)H2, Complex 4. One representative semicarbazone of heterocyclic β‐diketone (L(4)H2) and its corresponding dimethyltin(IV) complex Me2SnL(4) (Complex 4) were also studied using computational method (DFT‐B3LYP). Optimized molecular structure, bond lengths, bond angles, EHOMO, ELUMO, dipole moment, polarizability, and other global reactivity parameters were calculated. Energy gap (ΔE) of the ligand L(4)H2 and its corresponding complex has also been compared. Optimized molecular structure–antidiabetic activity relationship of two representative ligands and the corresponding complexes has also been studied. The unified hybrid pharmacophores exhibited robust antidiabetic activity.

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Crystallographic study of rhinoliths

Abstract: Five nasal stones were extracted from five patients. The etiology and clinical picture have been discussed. The stones were analysed by a crystallographic method, using an X-ray diffraction technique. Their composition was identified as calcium phosphate.

Cited by 14 publications

References 7 publications

The Rhinolith—A Possible Differential Diagnosis of a Unilateral Nasal Obstruction

The Rhinolith—A Possible Differential Diagnosis of a Unilateral Nasal Obstruction

Experimental and theoretical approaches on structural, spectroscopic (FT‐IR and UV‐Vis), nonlinear optical, and molecular docking analyses for Zn (II) and Cu (II) complexes of 6‐chloropyridine‐2‐carboxylic acid

De novo unified robust antidiabetic pharmacophores based on biopotent hybrid material: DFT‐assisted design, optimized molecular structure, and understanding mechanism of antidiabetic bioassay

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