Crystalloids in salivary gland lesion: A diagnostic clue

Kishore, Manjari; Kaushal, Manju; Dogra, Shruti

doi:10.4103/jlp.jlp_120_18

Cited by 5 publications

(11 citation statements)

References 5 publications

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“…They appear reddish‐brown with Millon's stain and deep purplish red with the diazotization coupling method, confirming the presence of tyrosine 3 . Other types of crystalloids, which can be seen in salivary gland lesions, include collagenous, calcium oxalate, and amylase 4 . Collagenous crystalloids are nonrefractile radially arranged needle‐shaped fibers of collagen and are usually seen in pleomorphic adenomas and myoepitheliomas.…”

Section: Figurementioning

confidence: 91%

Tyrosine‐rich crystalloids: A potential clue to cytodiagnosis of pleomorphic adenoma

Kothari

Agnihotri

2023

Diagnostic Cytopathology

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Section: Figurementioning

confidence: 91%

Tyrosine‐rich crystalloids: A potential clue to cytodiagnosis of pleomorphic adenoma

Kothari

Agnihotri

2023

Diagnostic Cytopathology

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“…Amylase crystalloids are crystalline structures that are variably rhomboid, rectangular, and needlelike in shape that are predominantly associated with nonneoplastic salivary gland disease, such as sialadenitis and benign cysts, but can also be found associated with neoplastic lesions including WT and pleomorphic adenoma. [20][21][22][23][24][25][26][27][28] Amylase crystalloids are likely an underrecognized and underreported finding in cytology (in all 3 cases in the current study cohort, amylase crystalloids were not noted on prospective review). However, their recognition can be helpful especially for FNA cases where a malignant lesion is being considered.…”

Section: Cancer Cytopathology September 2022mentioning

confidence: 98%

The Milan System classification of Warthin tumor: A large institutional study of 124 cases highlighting cytologic features that limit definitive interpretation

Torous

Faquin

2022

Cancer Cytopathology

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BACKGROUND Fine‐needle aspiration (FNA) is highly accurate for the diagnosis of Warthin tumor (WT). However, there is a minor subset of WT cases that are more challenging to interpret. The goal of this study is to identify factors that limit definitive diagnosis of WT on FNA. METHODS All WT surgical specimens diagnosed during a 6.5‐year study period were retrospectively identified and the preceding cytologic specimen diagnostic categories were analyzed. Of particular interest were WT cases with indeterminate or malignant interpretations. Cases that noted squamous or mucinous change in either the surgical or cytologic reports were also reviewed. RESULTS A total of 157 WT surgical specimens were identified, with 124 (79.0%) having prior FNAs. The distribution of cytologic diagnostic categories was 12 (9.7%) nondiagnostic, 10 (8.1%) nonneoplastic, 13 (10.5%) atypia of undetermined significance (AUS), 82 (66.1%) neoplasm: benign, 4 (3.2%) salivary gland neoplasm of uncertain malignant potential (SUMP), 2 (1.6%) suspicious for malignancy, and 1 (0.8%) malignant. Of the 20 cases in indeterminate/malignant categories, a majority noted either squamoid (9 of 20) or mucinous (2 of 20) changes. The remainder noted scant cellularity as a limiting factor to interpretation. Additionally, 27 cases mentioned squamous or mucinous change in the surgical or cytology report, with a wide spectrum of cytologic categorization including 2 (7.4%) nondiagnostic, 2 (7.4%) nonneoplastic, 7 (25.9%) AUS, 8 (29.6%) neoplasm: benign, 4 (14.8%) SUMP, 2 (7.4%) suspicious for malignancy, and 1 (3.7%) malignant. CONCLUSIONS This study identified 2 key causes for indeterminate or misclassification of WT on FNA: specimen hypocellularity and metaplastic changes. Recognition of the potential for squamous and mucinous metaplastic changes combined with observance of some helpful diagnostic clues such as the presence of crystalloids may aid in preventing diagnostic pitfalls.;

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“…[10][11][12] Amylase crystalloids are mostly associated with nonneoplastic conditions including duct obstruction, sialadenitis, oncocytic cysts or cystadenomas, developmental cysts, and lymphoepithelial cysts. 1,[10][11][12][13][14][15][16][17][18] They have also been reported in association with Warthin tumors, which are benign neoplastic lesions. 1,19 Based on the current literature, amylase crystalloids have not been found in association with malignancy.…”

Section: Amylase Crystalloidsmentioning

confidence: 99%

“…Amylase crystalloids are mostly associated with nonneoplastic conditions including duct obstruction, sialadenitis, oncocytic cysts or cystadenomas, developmental cysts, and lymphoepithelial cysts 1,10–18 . They have also been reported in association with Warthin tumors, which are benign neoplastic lesions 1,19 .…”

Section: Salivary Glandmentioning

confidence: 99%

Crystals and crystalloids in cytopathology: Incidence and importance

Torous

Dodd

McIntire

et al. 2022

Cancer Cytopathology

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Many crystals and crystal‐like structures may be encountered in cytopathology practice and can represent both beautiful novelties and diagnostic aids. The authors present an organ‐specific review of the published literature on crystals combined with personal experiences. The purpose is not only to serve as a reference guide by highlighting the clinical and morphologic features of crystals, crystalloids, and crystal‐like structures but also to review their significance and to offer reporting strategies in cases that bear management implications.

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Crystalloids in salivary gland lesion: A diagnostic clue

Cited by 5 publications

References 5 publications

Tyrosine‐rich crystalloids: A potential clue to cytodiagnosis of pleomorphic adenoma

Tyrosine‐rich crystalloids: A potential clue to cytodiagnosis of pleomorphic adenoma

The Milan System classification of Warthin tumor: A large institutional study of 124 cases highlighting cytologic features that limit definitive interpretation

Crystals and crystalloids in cytopathology: Incidence and importance

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