Crystalloids in salivary gland lesions

Issac, Reeba Mary; Oommen, Annamma Madathil; Mathai, Jessy Mangalathu

doi:10.4103/0970-9371.151129

Cited by 9 publications

(9 citation statements)

References 5 publications

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“…Several types of crystalline structures such as amylase, tyrosine, collagenous, oxalate and intraluminal crystalloids have been illustrated in neoplastic and nonneoplastic lesions of salivary gland [5,6,[15][16][17]. Alpha-amylase (α-amylase) crystalloids are the most frequently encountered, non-birefringent, rhomboid-shaped structures with pointed ends that stain deep blue by MGG, bright orange with PAP, and pink by H&E. They range from 5 μm to 500 μm in size.…”

Section: Discussionmentioning

confidence: 99%

“…Collagenous crystalloids are observed as radially-arranged needle-shaped fibers of collagen. Intraluminal crystalloids composed of dense amorphous eosinophilic material are identified in malignant salivary gland tumors [5,[15][16][17].…”

Section: Discussionmentioning

confidence: 99%

“…α-amylase crystalloids have so far been reported only in benign lesions while tyrosine-rich crystalloids occur mainly in pleomorphic adenomas and rarely in malignant salivary gland neoplasms. Collagenous crystalloids have been detected in pleomorphic adenomas and myoepitheliomas [15,16].…”

Section: Discussionmentioning

confidence: 99%

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Oncocytic Papillary Cystadenoma with Tyrosine-rich Crystalloids in the Parotid: Case Report with Cytology and Histology Correlation and Literature Review

Musayev¹,

Önal²

2015

J Cytol Histol

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Oncocytic papillary cystadenomas are rare benign salivary gland neoplasms. Minor salivary glands are frequent localization for this neoplasm. We report a case of oncocytic papillary cystadenoma of the parotid gland, occurring in a 53-year-old male as a slowly growing, well defined cystic nodule of 1.5 cm in diameter. Fine needle aspiration (FNA) was performed by using 25-gauge needle by the (cyto) pathologist. Few small sheets of epithelial and oncocytic degenerative cells with extensive granular debris on the background were observed on FNA smears. Few tabular or petal form, non-birefringent crystalloids were noted in the background of scanty cellular specimens composed predominantly of oncocytic cells. On histopathology, unilocular cystic lesion with papillary structures lined by oncocytic cells and tyrosine-rich crystalloids within the lumen were identified. In conclusion, oncocytic papillary cystadenoma is uncommon benign tumor in the parotid gland and can be accompanied by tyrosine-rich crystalloids. It is useful to be familiar with the type of the crystalloid as they may help in differentiating benign and malignant lesions. To the best of authors' knowledge, this is the second reported case of oncocytic papillary cystadenoma with crystalloids with cyto-histo correlation.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Oncocytic Papillary Cystadenoma with Tyrosine-rich Crystalloids in the Parotid: Case Report with Cytology and Histology Correlation and Literature Review

Musayev¹,

Önal²

2015

J Cytol Histol

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“…They have been found predominantly in association with nonneoplastic salivary gland disease, which includes sialadenitis, obstructive cysts, and crystalloid granuloma, although they have also rarely been found in association with some neoplastic lesions, including Warthin tumor and pleomorphic adenoma. [2][3][4][5][6][7][8][9] It has been indicated that the presence of a cystic space, which results from salivary stasis, is crucial for the formation of amylase crystalloids, likely because α-amylase becomes condensed in supersaturated saliva and undergoes crystallization in the cystic space. 6,8,9 Tyrosine crystalloids, conversely, have been identified more frequently in association with salivary gland neoplasms, most commonly benign neoplasms and specifically pleomorphic adenomas; however, there have been rare reported cases of tyrosine crystalloids in adenoid cystic carcinoma and polymorphous (low-grade) adenocarcinoma.…”

Section: Introductionmentioning

confidence: 99%

Crystalloids in FNA specimens of salivary gland lesions: A retrospective study in a single large institute

Faquin

Torous

2020

Cancer Cytopathology

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BACKGROUND:Identifying crystalloids, which includes amylase and tyrosine crystalloids, is relatively uncommon in salivary gland fine-needle aspiration (FNA) cytology. Although it has been suggested that the presence of crystalloids favors a benign process, the full significance has not been well established. METHODS: The authors performed a review of slides from all salivary gland FNA cases received in their laboratory from January 2017 to September 2019 to identify cases with crystalloids (screened cohort). In addition, the departmental archives were searched retrospectively for all salivary gland FNA cases that had specifically reported crystalloids. Cytologic findings as well as correlation with surgical pathology and clinical follow-up were examined. RESULTS: There were 664 cases in the screened cohort. Crystalloids were present in 37 cases (incidence, 5.6%). Amylase crystalloids were the most commonly identified (n = 28; 75%), followed by tyrosine crystalloids (n = 4; 11%), and collagenous crystalloids (n = 1; 3%). Four cases with crystalloids could not be further classified because of low quantity (n = 4; 11%). An additional 54 cases were identified in the 10-year retrospective review. Diagnostic categorization for the total cohort (N = 91) was as follows: nondiagnostic, 30 cases (33%); nonneoplastic/benign, 42 cases (46%); neoplasm: benign, 10 cases (11%); and atypia of undetermined significance, 9 cases (10%). Twenty-six cases had subsequent resection findings, including oncocytic cyst/cystadenoma in 8 cases (31%), chronic sialadenitis/ductal obstructive change in 7 cases (27%), pleomorphic adenoma in 5 cases (27%), developmental cyst in 3 cases (12%), lymphoepithelial cyst in 2 cases (8%), and Warthin tumor in 1 case (4%). CONCLUSIONS: This cohort represents the largest FNA series of salivary gland crystalloids. All cases were associated with nonneoplastic or benign neoplastic lesions.

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“…Amylase crystalloids are so far encountered with only in benign lesions including chronic sialadenitis, unilocular cysts, lymphoepithelial cysts and Warthin's tumor. [ 1 7 ]…”

mentioning

confidence: 99%

Amylase crystalloids in fine needle aspiration cytology of parotid gland: A diagnostic challenge

2015

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Crystalloids in salivary gland lesions

Cited by 9 publications

References 5 publications

Oncocytic Papillary Cystadenoma with Tyrosine-rich Crystalloids in the Parotid: Case Report with Cytology and Histology Correlation and Literature Review

Oncocytic Papillary Cystadenoma with Tyrosine-rich Crystalloids in the Parotid: Case Report with Cytology and Histology Correlation and Literature Review

Crystalloids in FNA specimens of salivary gland lesions: A retrospective study in a single large institute

Amylase crystalloids in fine needle aspiration cytology of parotid gland: A diagnostic challenge

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