On 14 August 2021, an earthquake of moment magnitude Mw = 7.2 hit Haiti Island. Unfortunately, it caused several victims and economic damage to the island. While predicting earthquakes is still challenging and has not yet been achieved, studying the preparation phase of such catastrophic events may improve our knowledge and pose the basis for future predictions of earthquakes. In this paper, the six months that preceded the Haiti earthquake are analysed, investigating the lithosphere (by seismic catalogue), atmosphere (by climatological archive) and ionosphere by China Seismo-Electromagnetic Satellite (CSES-01) and Swarm satellites, as well as Total Electron Content (TEC) data. Several anomalies have been extracted from the analysed parameters using different techniques. A comparison, especially between the different layers, could increase or decrease the probability that a specific group of anomalies may be (or not) related to the preparation phase of the Haiti 2021 earthquake. In particular, two possible coupling processes have been revealed as part of the earthquake preparation phase. The first one was only between the lithosphere and the atmosphere about 130 days before the mainshock. The second one was about two months before the seismic event. It is exciting to underline that all the geo-layers show anomalies at that time: seismic accumulation of stress showed an increase of its slope, several atmospheric quantities underline abnormal atmospheric conditions, and CSES-01 Ne depicted two consecutive days of ionospheric electron density. This suggested a possible coupling of lithosphere–atmosphere and ionosphere as a sign of the increased stress, i.e., the impending earthquake.