CSF 5-Hiaa and Suicide in Non-Depressed Schizophrenics

Praag, Herman van

doi:10.1016/s0140-6736(83)90501-9

Cited by 200 publications

(50 citation statements)

References 15 publications

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“…Suicidal patients with and without depression have lower levels of CSF 5-HIAA (Träskman, Å sberg, Bertilsson, & Sjö strand, 1981). In schizophrenia the association between low CSF 5-HIAA and suicidality (Ninan et al, 1984), even in nondepressed schizophrenic patients (van Praag, 1983), suggests to van Praag (1982 and Ninan and colleagues (1984) that low CSF 5-HIAA may be a marker of aggressive behavior in general, reflecting disturbance in regulation or inhibition (impulsivity) of aggressive behavior.…”

Section: Genes Neurotransmitters and Impulsive Aggression In Schizomentioning

confidence: 99%

Schizophrenia and impulsive aggression: A heuristic inquiry with forensic and clinical implications

Felthous

2008

Behavioral Sci & The Law

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Assessment of a violent act committed by an offender with schizophrenia typically focuses on whether the act was due to distortions in thought or perception, i.e., delusions or hallucination. An important but less appreciated feature is the impulsivity of the act, which can have forensic and therapeutic implications. Here a modification of Barratt's classification of aggressive behavior is presented that includes premeditated (instrumental), medical (secondary), impulsive (expressive), and compulsive (instrumental and expressive) aggression. Violence due to a mental condition such as schizophrenia is considered medical, but even aggression motivated by delusions or hallucinations can also be characterized as impulsive, premeditated, or compulsive.Although research on aggression and schizophrenia is limited with regard to the impulsivity-premeditation dimension and difficult to compare, current evidence suggests this to be an important consideration in the assessment of aggression in individuals with schizophrenia, important both forensically and therapeutically. Future research on the impulsive-premeditated quality of aggressive acts by offenders with schizophrenia--research wherein aggressive behavior is defined, situational context is clarified, and diagnostic criteria are explicitly followed--should further refine our understanding of the nature of aggressive acts associated with schizophrenia. Findings from such research will undoubtedly inform assessment, treatment, and forensic relevance of schizophrenia-related physical aggression.

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Section: Genes Neurotransmitters and Impulsive Aggression In Schizomentioning

confidence: 99%

Schizophrenia and impulsive aggression: A heuristic inquiry with forensic and clinical implications

Felthous

2008

Behavioral Sci & The Law

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“…With regard to 3 H-Par binding parameters, the OCD patients had a statistically significant lower density (B max , fmol/mg protein, mean B SD) of 3 OCD patients showed a trend towards a negative correlation between Y-BOCS total score and the suspiciousness factor of the BDHI that was not, however, statistically significant.…”

Section: Resultsmentioning

confidence: 84%

“…An inverse relationship between 5-hydroxyindoleacetic acid levels and a past history of suicide attempts [1] has been widely reported, and this finding has been extended to suicide attempters with diagnoses of conditions other than depression [2,3] to subjects who exhibit aggression towards others [4] and to subjects suffering from personality disorders characterized by aggressive traits [5][6][7]. A blunted prolactin response that was inversely correlated with measures of aggression and impulsivity, following dfenfluramine, a 5-HT releaser and re-uptake blocker, has been observed constantly in aggressive subjects with different psychiatric disorders [7][8][9].…”

Section: Introductionmentioning

confidence: 99%

No Correlation between Aggression and Platelet <sup>3</sup>H-Paroxetine Binding in Obsessive-Compulsive Disorder Patients

et al. 2001

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Different findings suggest that the serotonin (5-HT) system may be involved in both the regulation of aggression and the pathophysiology of obsessive-compulsive disorder (OCD). Our study aimed to evaluate the aggressive features of a group of OCD patients and to explore possible correlations with a serotonergic marker, namely platelet 5-HT transporter. Psychopathological and biological patterns were compared with those of a group of healthy controls and those of patients with major depression. Twenty-one patients affected by OCD, 21 by depression and 21 healthy controls were included in the study. Aggressive features were measured by means of the Buss and Durkee Hostility Inventory (BDHI). The platelet 5-HT transporter was evaluated by means of the ³H-paroxetine binding parameters (maximum binding capacity, B_max and dissociation constant, K_d). The OCD patients showed a total score on the BDHI not significantly different from that of healthy controls and lower than that of depressed patients. The factor profile was similar in the 3 groups, but higher in the depressed patients. The irritability, resentment, guilt, negativism and suspiciousness factors were significantly more pronounced in depressed patients. Some sex-related difference in single factors were also observed. The B_max of ³H-paroxetine binding was lower in OCD patients than in depressives or healthy controls. OCD patients were more similar to healthy controls than to depressed patients with regard to aggressive features measured by means of the BDHI. This suggests that aggression in OCD is a complex phenomenon that probably requires specific instruments of evaluation.

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“…The relation between lowered CSF 5-HIAA and au toaggression in depression was first reported by Asberg et al [12], but has now been confirmed by many investi gators [13,14], Nondepressed suicide attempters, nonpsychotic [15] as well as psychotic [16,17], showed the same disturbance and so did individuals with uncon trolled outward directed aggression [18,19], Comparing depressed patients with low and with normal CSF 5- HIAA we found additional evidence for a relation: de creased 5-HT metabolism/disturbed aggression regula tion. In the low 5-HIAA group, suicide rate was in creased and so were signs of outward directed aggression [20] (table 7).…”

Section: Serotonin and Depressionmentioning

confidence: 75%

Moving Ahead Yet Falling Behind

Hm¹

1989

Neuropsychobiology

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The progress of psychiatry over the past few years is impressive. That process, however, is nonlinear and in this paper three developments in depression research are discussed and thought to be counterproductive. First, the depression classification as institutionalized by the DSM-III is an unfocused and confusing one. The regular revisions, moreover, largely based on the opinions of experts rather than on the research by experts, add to the confusion. Second, the preoccupation of biological psychiatry with nosology is seen as a growth-inhibiting factor. The functional/dimensional approach searching for correlations between biological and psychological dysfunctions, an approach we have been advocating for many years, seems to have great potential and deserves to be included in mainstream biological psychiatry. Finally, the ‘biologization’ of depression research went too far. The conception of depression as a brain disease is a ‘terrible simplification’, even for the syndrome considered to be the most ‘biological’ of all: major depression, melancholic type. Psychological determinants of the brain dysfunctions underlying depressive disorders deserve as much scientific scrutiny as their biological counterparts. Te mind should not be the soft belly of (biological) psychiatry.

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CSF 5-Hiaa and Suicide in Non-Depressed Schizophrenics

Cited by 200 publications

References 15 publications

Schizophrenia and impulsive aggression: A heuristic inquiry with forensic and clinical implications

Schizophrenia and impulsive aggression: A heuristic inquiry with forensic and clinical implications

No Correlation between Aggression and Platelet <sup>3</sup>H-Paroxetine Binding in Obsessive-Compulsive Disorder Patients

Moving Ahead Yet Falling Behind

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