CSF and plasma cytokines at delivery and postpartum mood disturbances

Boufidou, Fotini; Lambrinoudaki, I.; Argeitis, John; Zervas, Ioannis; Pliatsika, Paraskevi; Leonardou, Aggeliki A.; Petropoulos, G.; Hasiakos, D; Papadias, K; Nikolaou, Chryssoula

doi:10.1016/j.jad.2008.07.008

Cited by 101 publications

(78 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The lack of cross-sectional association between inflammatory markers and depressive symptoms in the present sample replicates the findings of previous studies of these biomarkers during pregnancy 10,11 and the postpartum period 15,16 which use the EPDS to assess depressive symptoms. Our study is also consistent with the prospective study conducted by Scrandis et al, who found no association between pregnancy CRP levels and postpartum depressive symptoms.…”

Section: Discussionsupporting

confidence: 88%

“…13 One study has shown a positive relationship between depressive symptoms and transforming growth factor beta (TGF-b), 14 while two others have failed to observe any association between postpartum depressive symptoms and markers of inflammation. 15,16 Prospective studies examining depressive symptoms and inflammatory markers from pregnancy to postpartum are also inconclusive. Maes et al have published three studies examining postpartum blues (symptoms of depression which occur between 24-48 hours after birth and 2 weeks postpartum).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Relationship between inflammatory biomarkers and depressive symptoms during late pregnancy and the early postpartum period: a longitudinal study

Simpson

Steiner

Coote

et al. 2016

Rev. Bras. Psiquiatr.

View full text Add to dashboard Cite

Objective: Perinatal depressive symptoms often co-occur with other inflammatory morbidities of pregnancy. The goals of our study were 1) to examine whether changes in inflammatory markers from the third trimester of pregnancy to 12 weeks postpartum were associated with changes in depressive symptoms; 2) to examine whether third trimester inflammatory markers alone were predictive of postpartum depressive symptoms; and 3) to examine the relationship between inflammatory markers and depressive symptoms during the third trimester of pregnancy and at 12 weeks postpartum. Methods: Thirty-three healthy pregnant women were recruited from the Women's Health Concerns Clinic at St. Joseph's Healthcare in Hamilton, Canada. The impact of depressive symptoms on the levels of interleukin (IL)-6, IL-10, tumor necrosis factor alpha (TNF-a), and C-reactive protein (CRP) at the third trimester of pregnancy, at 12 weeks postpartum, and across time was assessed using linear and mixed-model regression. Results: Regression analysis revealed no significant association between depressive symptoms and any of the candidate biomarkers during pregnancy, at 12 weeks postpartum, or over time. Pregnancy depressive symptoms (p 4 0.001), IL-6 (p = 0.025), and IL-10 (p = 0.006) were significant predictors of postpartum Edinburgh Perinatal Depression Scale (EPDS) score. Conclusions: Our study supports previous reports from the literature showing no relationship between inflammatory biomarkers and depressive symptoms during late pregnancy, early postpartum, or across time. Our study is the first to observe an association between late pregnancy levels of IL-6 and IL-10 and postpartum depressive symptoms. Further studies with larger samples are required to confirm these findings.

show abstract

Section: Discussionsupporting

confidence: 88%

Section: Introductionmentioning

confidence: 99%

Relationship between inflammatory biomarkers and depressive symptoms during late pregnancy and the early postpartum period: a longitudinal study

Simpson

Steiner

Coote

et al. 2016

Rev. Bras. Psiquiatr.

View full text Add to dashboard Cite

show abstract

“…In addition, regardless of mode of delivery, healing processes occur following delivery which may instigate inflammatory responses [57]. In addition to affecting the healing process, functioning of the immune system following childbirth may have clinical implications for risk of postpartum mood disorders [58,59]. Moreover, certain autoimmune diseases including rheumatoid arthritis and multiple sclerosis tend to remit during pregnancy, but become exacerbated at postpartum [60,61].…”

Section: Discussionmentioning

confidence: 99%

33. Longitudinal changes in serum proinflammatory markers across pregnancy and postpartum: Effects of maternal body mass index

Christian

Porter

2014

Brain, Behavior, and Immunity

View full text Add to dashboard Cite

“…In animal and clinical research, the kynurenine:tryptophan ratio has been used as a marker of in lammation correlated with postpartum depressive behaviours and states. In lammatory messengers, or cytokines IL6 and TNF-alpha, have been demonstrated to be elevated in the cerebrospinal luid of women at the time of their childbirth, who then presented with depression at 6 weeks postpartum 12 . Similarly, elevated levels of IL-1B predicted depressive symptoms at 1 month postpartum 9 .…”

Section: In Lammatory Underpinningsmentioning

confidence: 99%

Putting theory into preliminary practice: Neuroinflammatory models of postpartum depression

Brogan¹

2013

OA Alternative Medicine

View full text Add to dashboard Cite

CSF and plasma cytokines at delivery and postpartum mood disturbances

Cited by 101 publications

References 31 publications

Relationship between inflammatory biomarkers and depressive symptoms during late pregnancy and the early postpartum period: a longitudinal study

Relationship between inflammatory biomarkers and depressive symptoms during late pregnancy and the early postpartum period: a longitudinal study

33. Longitudinal changes in serum proinflammatory markers across pregnancy and postpartum: Effects of maternal body mass index

Putting theory into preliminary practice: Neuroinflammatory models of postpartum depression

Contact Info

Product

Resources

About