2010
DOI: 10.1016/j.jneuroim.2010.03.004
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CSF chemokine alterations related to the clinical course of amyotrophic lateral sclerosis

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Cited by 97 publications
(112 citation statements)
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“…Nevertheless, CCR1 and CCR5 are receptors of MIP‐1α, which differ from those of MCP‐1 and may explain the differential effects between MIP‐1α and MCP‐1, although the complex relationship between chemokine and receptor is still vague. In the light of previous results demonstrating a correlation between MCP‐1 levels and disease severity (Tateishi et al., 2010), our study suggests that MCP‐1 has a predictive value for ALS progression and is possibly neurotoxic. In addition, similar conclusions were reached in our previous report that MIP‐1α is likely neuroprotective and possibly can monitor disease progression (Yang et al., 2016).…”
Section: Discussionmentioning
confidence: 63%
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“…Nevertheless, CCR1 and CCR5 are receptors of MIP‐1α, which differ from those of MCP‐1 and may explain the differential effects between MIP‐1α and MCP‐1, although the complex relationship between chemokine and receptor is still vague. In the light of previous results demonstrating a correlation between MCP‐1 levels and disease severity (Tateishi et al., 2010), our study suggests that MCP‐1 has a predictive value for ALS progression and is possibly neurotoxic. In addition, similar conclusions were reached in our previous report that MIP‐1α is likely neuroprotective and possibly can monitor disease progression (Yang et al., 2016).…”
Section: Discussionmentioning
confidence: 63%
“…In our study, elevated interleukin levels comprising IL‐2, IL‐6, IL‐10, IL‐15, and IL‐17 were noted in the serum from ALS patients, whereas only IL‐15 and IL‐17 were clearly increased in the CSF. One possible explanation for the difference observed from the CSF and serum is that IL‐2, IL‐6, and IL‐10 might have a limited input in central nervous system (CNS) during the inflammatory process; as one previous study has shown, these cytokines are at similar levels in the CSF of ALS patients and control subjects (Tateishi et al., 2010). Furthermore, even IL‐2 and IL‐10 could not be detected in the CSF of ALS patients (Holmoy, Roos, & Kvale, 2006).…”
Section: Discussionmentioning
confidence: 99%
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