CSF omeprazole concentration and albumin quotient following high dose intravenous omeprazole in dogs

Girod, Maud; Allerton, Fergus; Vangrinsven, Emilie; Tutunaru, Alexandru-Cosmin; Marchin, Jérôme de; Gomez-Fernandez-Blanco, Carlos; Ruiz‐Nuño, Ana; Wojnicz, Aneta; Farnir, Fédéric; Gommeren, Kris; Peeters, Dominique

doi:10.1016/j.rvsc.2019.07.009

Cited by 2 publications

(1 citation statement)

References 37 publications

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“…The principle is that these drugs reduce CSF production thus reducing the driving force contributing to CM-P and SM. However, studies assessing the effect of omeprazole on CSF production by evaluating the albumen quotient (QAlb; ratio between CSF and serum albumin concentration) did not support a CSF-reducing effect (Girod and others 2016), although the validity of QAlb as a surrogate marker for CSF production was later disputed (Girod and others 2019). More importantly, omeprazole may not achieve a therapeutic choroid plexus concentration, so the effect, if any, of antacids on CSF production remains unsubstantiated.…”

Section: Medical Managementmentioning

confidence: 99%

New considerations about Chiari‐like malformation, syringomyelia and their management

Rusbridge¹

2020

In Practice

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Background: Chiari-like malformation (CM) is a developmental condition, characterised by a conformational change and overcrowding of the brain and cranial cervical spinal cord. CM-associated pain (CM-P) and syringomyelia are increasingly being diagnosed, due to the rising popularity of predisposed brachycephalic breeds and the availability of MRI in veterinary practices.Aim of the article: This article aims to update the veterinary profession on these conditions, and provides a guide to diagnosis and treatment of clinically relevant disease.

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Section: Medical Managementmentioning

confidence: 99%

New considerations about Chiari‐like malformation, syringomyelia and their management

Rusbridge¹

2020

In Practice

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Comprehensive comparative study of Chiari-like malformation in veterinary and human medicine

Jung,

Park,

Kim

et al. 2024

Vet. Med.

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This review aims to enrich our understanding of Chiari-like malformation (CLM) by combining human and veterinary insights, and providing a detailed cross-species overview. CLM is a developmental abnormality characterised by caudal displacement of the hindbrain into the foramen magnum due to an entire brain parenchymal shift caused by insufficient skull volume. This malformation leads to a progressive obstruction at the craniocervical junction, which disrupts the normal cerebrospinal fluid flow, leading to secondary syringomyelia. The clinical signs of CLM and syringomyelia include phantom scratching, head tilt, head tremor, ataxia, tetraparesis, pain, muscle atrophy, and scoliosis or torticollis. Magnetic resonance imaging remains the gold standard for diagnosing CLM, since it allows the visualisation of abnormal findings such as the caudal cerebellar herniation, caudal cerebellar compression from occipital dysplasia, and attenuated cerebrospinal fluid cisternae. Although various medical and surgical interventions, including foramen magnum decompression, can provide temporary symptomatic/ clinical sign relief, current literature shows a lack of sustained long-term efficacy. Therefore, additional research is needed to evaluate the long-term effects of existing treatment strategies and to compare different techniques utilised in conjunction with foramen magnum decompression.

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CSF omeprazole concentration and albumin quotient following high dose intravenous omeprazole in dogs

Cited by 2 publications

References 37 publications

New considerations about Chiari‐like malformation, syringomyelia and their management

New considerations about Chiari‐like malformation, syringomyelia and their management

Comprehensive comparative study of Chiari-like malformation in veterinary and human medicine

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