Csf polyamines: A new and important means of monitoring patients with medulloblastoma

Marton, Laurence J.; Edwards, Michael S. B.; Levin, Victor A.; Lubich, Warren P.; Wilson, Charles B.

doi:10.1002/1097-0142(19810215)47:4<757::aid-cncr2820470421>3.0.co;2-7

Cited by 67 publications

(12 citation statements)

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“…Both Fulton [24] and Marton [25] showed that some patients with medulloblastoma had increased polyamines and repeated CSF polyamine determinations are accepted as a benefit in control of patients with medulloblastoma [23,[26][27][28]. Edwards et al [29] and Felzenhauser et al [30] have shown no false positives in more than 100 children in remission from medulloblastoma.…”

Section: Discussionmentioning

confidence: 99%

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Red blood cell polyamines as a diagnostic indicator of glioma presence and recurrence

Elworthy¹,

Hitchcock

1989

J Neuro-Oncol

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Red blood cell (RBC) polyamines, spermine and spermidine have been assayed from 103 patients with confirmed intracranial tumours and 87 controls. For spermine the test had a specificity of 97% and a sensitivity of 30% in preoperative patients, increasing to 40% in glioma patients. Tumour recurrence in postoperative patients gave a sensitivity of 48% increasing to 60% in glioma groups. For initial tumour presentation, therefore, this test is suggestive, though not unequivocal, of tumour presence. Its major role probably lies in monitoring the progress of the patient and its major importance in the detection of tumour recurrence.

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Section: Discussionmentioning

confidence: 99%

“…1 and 2. Marton [25] found that clinical changes could precede elevation of CSF polyamines. Our experience with RBC polyamines is similar but the spermine levels appear to reflect the clinical situation in the majority of the cases of recurrence.…”

Section: Discussionmentioning

confidence: 99%

Red blood cell polyamines as a diagnostic indicator of glioma presence and recurrence

Elworthy¹,

Hitchcock

1989

J Neuro-Oncol

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“…Cerebrospinal fluid samples were prepared according to Marton et al (15), including acid hydrol-. ysis to yield total polyamines.…”

Section: Methodsmentioning

confidence: 99%

“…This was found to correlate well with the degree of malignancy of these tumors (12). Extensive efforts have been made to establish the potential of CSF polyamine levels in both long-term and short-term evaluation of the efficacy of therapies for patients with brain tumors (13)(14)(15)(16)(17)(18)(19).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of polyamine levels in cerebrospinal fluid of children with brain tumors

1986

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Cerebrospinal fluid (CSF) polyamine levels were analyzed retrospectively in 21 pediatric patients with different types of intracranial malignant tumors to determine the benefit of following these markers during the clinical management of brain tumors. The tumors included 16 medulloblastomas and 1 each of germinoma, ependymoma, primitive neuroectodermal tumor, astrocytoma, and malignant teratoma. The clinical course of each patient was followed by neurologic examination, cranial computed tomography, CSF cell count, and cytology after cytocentrifugation. The correlation of CSF putrescine and spermidine levels with the clinical course of the brain tumors was analyzed. The following results were obtained: (1) A significant increase in CSF putrescine levels was observed in children with medulloblastoma when there was recurrent or metastatic disease in the sites close to the CSF pathway compared with the children whose disease status was stable after successful treatment (P less than 0.005). (2) The increase of CSF putrescine levels was the earliest predictor of recurrence or metastasis near the CSF pathway. (3) In tumors other than medulloblastoma, the levels of polyamines were not predictive of disease activity with the possible exception of germinoma. (4) Spermidine levels in the CSF were of limited clinical importance for patients with brain tumors. CSF putrescine levels may be the earliest and most sensitive quantitative marker of the progression of medulloblastoma, and their evaluation should be included in the diagnostic work-up and follow-up examination of children with medulloblastoma.

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“…In some institutions, protocols call for repeat CSF cytological examination 10-14 days after surgery if the only positive study is a positive cytology in the immediate post-operative period. Some centers are also measuring CSF polyamines (putrescine and spermidine) as evidence of dissemination [56].…”

Section: Disseminationmentioning

confidence: 99%

Surgical management of medulloblastoma

1996

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Recent technological aids and understanding of pathophysiology has made the surgery of medulloblastoma safer. The guiding principle for the neurosurgeon remains removal of bulky disease, but there is no justification for removal of small amounts of tumor from critical locations. Post-operative complications include hydrocephalus, hematoma, mutism, asceptic meningitis, gastroinstestinal hemorrhage, and cervical instability. Staging is best done preoperatively with MRI, and presence of dissemination remains the most important prognostic factor in this disease. Postoperative surveillance imaging is of questionable value.

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Csf polyamines: A new and important means of monitoring patients with medulloblastoma

Cited by 67 publications

References 1 publication

Red blood cell polyamines as a diagnostic indicator of glioma presence and recurrence

Red blood cell polyamines as a diagnostic indicator of glioma presence and recurrence

Evaluation of polyamine levels in cerebrospinal fluid of children with brain tumors

Surgical management of medulloblastoma

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