CSF prostaglandin D synthase is reduced in excessive daytime sleepiness

Hersberger, Martin; Baumann, Christian R.

doi:10.1007/s00415-006-0153-8

Cited by 18 publications

(8 citation statements)

References 15 publications

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“…PGDS is an enzyme necessary for the production of prostaglandin D 2 (PGD 2 ), a substance with somnogenic activity in mammals (Huang et al 2007). The infusion of selective inhibitors of PGDS reduces sleep amounts in rats, concomitant with a reduction of PGD 2 content in the brain (Qu et al 2006), and serum PGDS concentrations are reduced during both enforced sleep deprivation as well as during excessive daytime sleepiness in humans (Jordan et al 2004;Bassetti et al 2006). Thus, the differential expression of PGDS during sleep restriction in the sparrow suggests that prostaglandin D 2 may play a similar role in avian sleep regulation.…”

Section: Discussionmentioning

confidence: 99%

Changes in brain gene expression during migration in the white-crowned sparrow

Jones

Pfister-Genskow

Cirelli

et al. 2008

Brain Research Bulletin

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Long-term recordings of seasonal sleep patterns in captive white-crowned sparrows (Zonotrichia leucophrys gambelii) have shown that these birds markedly reduce sleep time during the migratory period relative to the non-migratory period. It was also found that, despite this sleep reduction, sparrows showed no evidence of neurobehavioral deficits in a standard operant task used to assess the effects of sleep loss. In this study, we performed an extensive microarray analysis of gene expression in the sparrow telencephalon during the migratory season (M), relative to a 78-hour period of enforced sleep restriction during the non-migratory season (SR), and a 6-hour period of normal wakefulness during the non-migratory season (W). Of the estimated 17,100 transcripts that were reliably detected, only 0.17% changed expression as a function of M (relative to both SR and W), and 0.11% as a function of SR (relative to both M and W). Brain transcripts whose expression increased during M include the facilitated glucose transporter GLUT1, the presenilin associated rhomboid-like protein PARL, and several members of the heat shock protein family, such as HSP70, HSP90, GRP78 and BiP. These data suggest that migration is associated with brain cellular stress and enhanced energetic demands.

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Section: Discussionmentioning

confidence: 99%

Changes in brain gene expression during migration in the white-crowned sparrow

Jones

Pfister-Genskow

Cirelli

et al. 2008

Brain Research Bulletin

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“…It is therefore possible that, in humans, histaminergic transmission may also fluctuate according to sleep pressure and decrease in the presence of EDS. Similarly, a downregulation was postulated to explain the recent observation of low levels of CSF prostaglandin D synthase, a brain enzyme with somnogenic effects, in 34 patients with narcolepsy and other forms of EDS (Bassetti et al ., 2006). In sum, low CSF histamine levels may result from an interaction between histaminergic neurons and different arousal (monoaminergic) systems and/or the cytokine/prostaglandins system (Bassetti et al ., 2006; Urade and Hayashi, 2000).…”

Section: Discussionmentioning

confidence: 99%

Cerebrospinal fluid histamine levels are decreased in patients with narcolepsy and excessive daytime sleepiness of other origin

Bassetti

Baumann

Dauvilliers

et al. 2010

Journal of Sleep Research

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SUMMARY Histaminergic neurons of the hypothalamic tuberomammillary nucleus constitute a major wake-promoting system. In animals, cerebrospinal fluid (CSF) histamine levels are increased during wakefulness and after sleep deprivation and decreased during sleep. An involvement of the histamine system in human disorders has not, to our knowledge, been reported. We measured hypocretin-1 and histamine levels in the lumbar CSF of 28 patients with and without excessive daytime sleepiness (EDS) as assessed by the Epworth Sleepiness Scale (ESS). There were 10 patients with EDS (ESS > 10, mean ESS = 14). Diagnoses included narcolepsy (n = 4), idiopathic hypersomnia (n = 2), sleep apnoea (n = 2) and multiple sclerosis (n = 2). Three patients were treated with stimulants. Their mean CSF histamine was 258 ± 159 PM. There were 18 patients without EDS (ESS < 9, mean ESS = 5). No patients were treated with stimulants. Their mean CSF histamine was significantly higher (624 ± 481 PM, P = 0.007). There was a significant inverse correlation (r = )0.48, P = 0.02) between ESS and both CSF histamine and hypocretin-1 levels. These observations suggest that narcolepsy and EDS of other origin are associated in humans with lower CSF histamine levels and therefore with a reduced activity of the wakepromoting histaminergic neuronal system. k e y w o r d s CSF, EDS, histamine, hypersomnia, hypocretin, narcolpesy, orexin

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“…271 Bassetti et al . 272 reported that CSF levels of L-PGDS are significantly lower in patients (n = 34) with excessive daytime sleepiness, when compared with levels in healthy controls (n = 22). Barcelo et al 273 reported that serum levels of L-PGDS are higher in obstructive sleep apnea patients with excessive daytime sleepiness than those without excessive daytime sleepiness.…”

Section: Prostaglandin D Synthases (Pgdss)mentioning

confidence: 95%