CSF tryptophan and transmitter amine turnover may predict social behaviour in the normal rat

Sahakian, Barbara J.; Sarna, G. S.; Kantamaneni, Devi B.; Jackson, Anne; Hutson, Peter H.; Curzon, G.

doi:10.1016/0006-8993(86)90612-8

Cited by 12 publications

(4 citation statements)

References 23 publications

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“…In this study, there were no differences in drinking outcomes in Type A (lower risldseverity) alcoholics taking fluoxetine or placebo. Thus, although it had been suggested that 5-HT agonist treatment may ameliorate 5-HT dysfunction (Kranzler and Anton, 1994;Pettinati, 1996), the results of this clinical study raised the , question of whether SSRIs could aggravate 5-HT dysfunction in some types of alcoholics Sahakian et al, 1986;Virkkunen and Narvanen, 1987). These findings warranted further evaluation using a different SSRI.…”

Section: Alcoholic Subtypes: 5-ht Dysfunction and Ssri Pharmacotherapymentioning

confidence: 74%

Sertraline Treatment for Alcohol Dependence: Interactive Effects of Medication and Alcoholic Subtype

Pettinati

Volpicelli

Kranzler

et al. 2000

Alcoholism Clin & Exp Res

195

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Section: Alcoholic Subtypes: 5-ht Dysfunction and Ssri Pharmacotherapymentioning

confidence: 74%

Sertraline Treatment for Alcohol Dependence: Interactive Effects of Medication and Alcoholic Subtype

Pettinati

Volpicelli

Kranzler

et al. 2000

Alcoholism Clin & Exp Res

195

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“…Again, these data point to the inverse relationship between hypothalamic and limbic 5-HT and aggression. In rats, however, neither 5-KT turnover nor DA turnover as measured in CSF samples were correlated to dominance in pairs of rats (Sahakian et al, 1986), but CSF tryptophan levels appeared predictive of dominance.…”

Section: Discussionmentioning

confidence: 88%

Serotonin Receptors and Animal Models of Aggressive Behavior

1995

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Various models of rodent agonistic behavior are described, which differentiate between offensive and defensive/flight models. Particular attention is given to one male and one female paradigm for offensive aggression, i.e. resident/intruder or territorial aggression (RI) and maternal aggression (MA). After an overview of the serotonin (5-HT) system in the CNS, a description is given of the ligands available. Subsequently, the effects of various drugs affecting serotonergic transmission in the RI- and MA-paradigms are described. The 5-HT1A receptor agonists busipirone, ipsapirone, and 8-OH-DPAT decreased aggression in RI and MA, but simultaneously led to a marked decrease in social interest and activity, indicative of a nonspecific antiaggressive profile. Nonselective 5-HT1 receptor agonists, such as RU24969, eltoprazine, and TFMPP reduced aggression quite specifically, did not decrease social interest or exploration, and sometimes even increased these behaviors. In RI and MA, the behavioral effects of these drugs were roughly similar. In contrast, MA was more sensitive to treatment with the 5-HT reuptake blocker fluvoxamine, which blocked RI aggression nonspecifically at the highest dose only. DOI, a 5-HT2A/2C# receptor agonist, decreased aggressive behavior and increased inactivity, without affecting social interest and exploration in RI as well as MA. This was, however, accompanied by "wet dog shaking" characteristic of 5-HT2 receptor stimulation. The nonspecific 5-HT receptor agonist (and 5-HT2 receptor antagonist) quipazine also induced "wet dog shaking" at doses which suppressed aggression, social interest, and exploration but increased inactive behaviors (sitting and lying). The discussion delineates a specific role for 5-HT1B receptor-subtype involvement in the modulation of aggression, with the restrictions we clearly face with regard to the lack of specific serotonergic agonists and antagonists for certain receptor subtypes. By and large, male and female rats react similarly to treatment with serotonergic drugs, and this fact underlines the consistent role of 5-HT in different forms of aggression.

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“…Plasma tryptophan and TRYP / LNAA were reported as increased in individuals with intermittent explosive disorder (Virkkunen and Narvanen 1987), and CSF tryptophan was elevated in rats with increased biting behavior (Sahakian et al 1986). Low tryptophan availability may, therefore, be associated with increased impulsive aggression in normals (Virkkunen and Linnoila 1990;Moeller et al 1996), but populations with impulsivity due to other serotonergic abnormalities may have normal or even increased TRYP / LNAA, perhaps as part of a compensatory mechanism for reduced serotonin synthetic capacity.…”

Section: Introductionmentioning

confidence: 98%

Relationships of plasma tryptophan availability to course of illness and clinical features of alcoholism: a preliminary study

et al. 1999

Psychopharmacology

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CSF tryptophan and transmitter amine turnover may predict social behaviour in the normal rat

Cited by 12 publications

References 23 publications

Sertraline Treatment for Alcohol Dependence: Interactive Effects of Medication and Alcoholic Subtype

Sertraline Treatment for Alcohol Dependence: Interactive Effects of Medication and Alcoholic Subtype

Serotonin Receptors and Animal Models of Aggressive Behavior

Relationships of plasma tryptophan availability to course of illness and clinical features of alcoholism: a preliminary study

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