Estimates show that Ghana losses approximately 30 percent of domestic revenue to corruption. Although losses due to corruption in Ghana’s extractive sector have not yet been quantified, the sector is plagued with incidents of corruption despite the country's commitment to international conventions, transparency mechanisms and best practices. A concerted efforts by state and nonactors is key to ease this canker. Understanding the role of CSOs and media in exposing corruption, promoting oversight and identifying the enablers and obstacles to their work is key to informing practise in the development space. This study examines the role of CSOs and media in the fight against extractive sector corruption. It identifies political economy factors that enable or hinder them in exposing corruption. Lastly, it identifies practical suggestions for surmounting the identified adverse political and economic factors. The research examines two cases of corruption, based on a desktop review and a survey of 11 state and non-state actors. A direct association between the role of CSOs and media and the level of corruption were established. Coalition building, using legal suits, sustaining advocacy, collaborations between media and CSOs are some enabling political economy factors identified. Inadequate resources to sustain advocacy, excessive duplicity of roles amongst oversight institutions, vested interests in extractive sector, inadequate prosecution of offenders by the legal system, inadequate evidence-based policy solutions by government, inadequate political will, limited access to information; little or no funding for legal action, increasing CSO and media employee turnover rates, are identified as some key political economy factors militating against efforts towards stemming corruption in Ghana’s extractive sector. These findings provide reliable information for CSOs and media in development practice, informs advocacy design, evaluates and improves media and CSO effectiveness in ridding the extractive sector of corruption.