CsOH×H2O in Organic Synthesis

Abstract

This feature focuses on a reagent chosen by a postgraduate, highlighting the uses and preparation of the reagent in current research CsOH⋅H 2 O in Organic SynthesisCompiled by Filipa Siopa Filipa Siopa was born in Portugal. She received her chemistry degree from Faculdade de Ciências of Universidade de Lisboa in 2003, and is now working towards her PhD under the supervision of Prof. Paula Branco at the Faculdade de Ciências e Tecnologia of Universidade Nova de Lisboa. Her current research is focused on understanding the role of catecholamines in several biological processes, namely the synthesis of catecholamine adducts of amino acids, nucleosides, and small peptides.

Efficient Synthesis of Quinazolinones by Transition‐Metal‐Free Direct Aerobic Oxidative Cascade Annulation of Alcohols witho‐Aminoarylnitriles

“…[21] In this sense, the widely available o-aminoarylnitriles [23] may be ac lass of preferable substrates because the reaction efficiency may be enhanced by avoiding hydrolytic side reactions of o-aminoarylamide substrates throughi nsitu generation of o-aminoarylamides by nitrile hydration. With our long-term interest in heterocycle construction [24] and development of alcohol-based green synthetic methods, [25] we have previously observed that bases can catalyze the aerobic oxidation of alcohols [24f,g, 25g] and that the "cesium effect" [26] can lead to efficient and controllable CsOHcatalyzed nitrile hydration and aminolysis reactions. [22] We thus envisionedan ew strategy for quinazolinone construction,t hat is, ab ase-catalyzed aerobic oxidative annulation of o-aminoarylnitrilesw ith alcohols (Scheme1G).…”