2022
DOI: 10.1186/s13244-022-01255-y
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CT and 18F-FDG PET abnormalities in contacts with recent tuberculosis infections but negative chest X-ray

Abstract: Close contacts of individuals with pulmonary tuberculosis are at risk for tuberculosis infection and the development of active tuberculosis. In current contact investigations, immunologic tests (the tuberculin skin test and interferon-gamma release assay) and chest X-ray examinations are used to dichotomize contacts with Mycobacterium tuberculosis infections into those with active (X-ray abnormalities) versus latent tuberculosis (normal radiographs). This article is a critical review of computed tomographic (C… Show more

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Cited by 7 publications
(2 citation statements)
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“…This study is the largest to systematically use high resolution imaging in asymptomatic contacts of TB and the first with prolonged follow-up in the absence of treatment and builds on our previous work to characterise and develop definitions for subclinical TB lesions. 15,20 We found that over three-quarters (76.9%) of asymptomatic, HIV-uninfected adults with a clinical diagnosis of latent TB who were confirmed to have culture positive pulmonary TB over a 5-year period had radiologically apparent infiltrative disease at baseline. Overall, of the 11.6% (29/250) who had baseline radiographic findings consistent with Subclinical TB disease, 34.5% (10/29) were subsequently diagnosed with culture positive TB, with 7/10 (70%) having drug resistance/WGS concordant with the index case.…”
Section: Discussionmentioning
confidence: 91%
“…This study is the largest to systematically use high resolution imaging in asymptomatic contacts of TB and the first with prolonged follow-up in the absence of treatment and builds on our previous work to characterise and develop definitions for subclinical TB lesions. 15,20 We found that over three-quarters (76.9%) of asymptomatic, HIV-uninfected adults with a clinical diagnosis of latent TB who were confirmed to have culture positive pulmonary TB over a 5-year period had radiologically apparent infiltrative disease at baseline. Overall, of the 11.6% (29/250) who had baseline radiographic findings consistent with Subclinical TB disease, 34.5% (10/29) were subsequently diagnosed with culture positive TB, with 7/10 (70%) having drug resistance/WGS concordant with the index case.…”
Section: Discussionmentioning
confidence: 91%
“… 54 2022 Challenges in TB research Challenges in developing new diagnostics and vaccines for TB control Perspective Yoon et al. 55 2022 CT and 18F-FDG PET abnormalities in contacts with recent tuberculosis infections but negative chest X-ray Systematic review of CT and PET-CT imaging of asymptomatic TB contacts with normal X-rays Systematic review Sossen et al. 4 2023 The Natural History of Untreated Pulmonary Tuberculosis in Adults: A Systematic Review and Meta-Analysis Quantify progression and regression across the spectrum of TB disease of individuals with untreated TB during the pre-chemotherapy era Systematic Review Agbota et al.…”
Section: Resultsmentioning
confidence: 99%