CT and MR findings in HIV-negative neurosyphilis

Peng, Fuhua; Xueqiang, Hu; Zhong, Xiufeng; Qiu, Wei; Jiang, Ying; Bao, Jiaqi; Wu, Ai-Min; Zhong, Pei

doi:10.1016/j.ejrad.2007.05.018

Cited by 57 publications

(61 citation statements)

References 13 publications

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“…Cerebral atrophy has frequently been found in neurosyphilis (Brightbill, Ihmeidan, Post, Berger, & Katz, 1995;Holland, Perrett, & Mills, 1986;Kodama et al, 2000;Luo et al, 2008;Peng et al, 2008;Yu et al, 2010;Zifko et al, 1996). Our finding of temporal lobe atrophy was also consistent with previous findings (Kodama et al, 2000;Yu et al, 2010).…”

Section: Discussionsupporting

confidence: 92%

Psychological/Cognitive Aspects in Untreated Neurosyphilis and Treatment with Penicillin G (A Case Study)

Muneoka

Kon²,

Kawabe³

et al. 2012

IJPS

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Active neurosyphilis is uncommon after the introduction of penicillin. We evaluated the pathology of a case of untreated neurosyphilis that was diagnosed as a manic episode. Examinations were performed before and after high-dose penicillin G treatment. Evaluations included the Mini-Mental State Examination (MMSE), the Neurobehavioral Cognitive Status Examination (Cognistat), the Bender Gestalt Test, an electroencephalogram, and brain magnetic resonance imaging/angiography. The most obvious improvements after treatment with penicillin G were the constructive ability and the ability to draw two-and three-dimensional designs. A paradoxical deterioration in several items on the Cognistat after treatment suggested an impairment in working memory. The clinical and psychological abnormalities observed in this case were speculated to be due to disturbed visual cognition related to encephalitis and impaired working memory related to temporofrontal lobe pathology. Current diagnostic tools were useful for precisely diagnosing and assessing the prognosis of older patients with late-onset mania

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Section: Discussionsupporting

confidence: 92%

Psychological/Cognitive Aspects in Untreated Neurosyphilis and Treatment with Penicillin G (A Case Study)

Muneoka

Kon²,

Kawabe³

et al. 2012

IJPS

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“…Existen otras pruebas inmunológicas para el diagnóstico de la enfermedad, como la PCR, la hemaglutinación, la microhemaglutinación, y los índices de inmunoglobulinas IgG, IgM, intratecales versus séricos, no disponibles en nuestro medio y cuyos resultados no son constantes (19,20).…”

Section: Discussionunclassified

Meningovascular neurosyphilis with basilar artery thrombosis, a case report and literature review

et al. 2011

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“…Arteritis was also observed in a few cases. Another report summarizing 14 HIV-negative patients demonstrated cerebral atrophy in 50%, nonspecific white matter lesion in 50%, cerebral infarction in 43%, arteritis in 29%, acute syphilitic meningitis and normal finding only in 7% (15). According to an investigation by Kodama et al, atrophy of the medial temporal lobe was seen in 3 of 7 cases (16), which was related to a prolonged personality change, general dementia, and general paresis (17).…”

Section: A B C Dmentioning

confidence: 97%

Neurosyphilis Is a Long-forgotten Disease but Still a Possible Etiology for Dementia

et al. 2015

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We herein report a heterosexual Japanese man in his forties who had been suffering from advanced dementia and personality change for 4 years. Positive results of a serological test for syphilis, Treponema pallidum hemagglutination assay, and fluorescent treponemal antibody-absorption test of both serum and cerebral spinal fluid led to the diagnosis of neurosyphilis. Jarisch-Herxheimer reaction was seen shortly after the first dose of penicillin was administered to the patient. His cognitive function did not recover after treatment. The incidence of syphilis has been reported to be increasing. Neurosyphilis should not be overlooked as an etiology for progressive dementia even in this post-antibiotic era.

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CT and MR findings in HIV-negative neurosyphilis

Cited by 57 publications

References 13 publications

Psychological/Cognitive Aspects in Untreated Neurosyphilis and Treatment with Penicillin G (A Case Study)

Psychological/Cognitive Aspects in Untreated Neurosyphilis and Treatment with Penicillin G (A Case Study)

Meningovascular neurosyphilis with basilar artery thrombosis, a case report and literature review

Neurosyphilis Is a Long-forgotten Disease but Still a Possible Etiology for Dementia

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