CT and MR of Neurofibromatosis of the Bladder

Shonnard, Keith M.; Jelinek, James S.; Benedikt, Richard A.; Kransdorf, Mark J.

doi:10.1097/00004728-199205000-00017

Cited by 39 publications

(20 citation statements)

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“…On sonograms, the thickened bladder wall is heterogeneous in echotexture with a lobular contour along the luminal margin (Fig 15) (12). CT scans show focal or diffuse mural thickening (26), which may have a low-attenuation ringlike or ropelike pattern that corresponds to the gross morphology of tortuous ropelike plexiform neurofibromas (Fig 16). Careful attention should be paid to the adjacent organs because these lesions may spread through the pelvis to involve other organs and the perineum (Fig 15b).…”

Section: Neurofibroma and Plexiform Neurofibromamentioning

confidence: 99%

Abdominal Neoplasms in Patients with Neurofibromatosis Type 1: Radiologic-Pathologic Correlation

Levy¹,

Patel²,

Dow³

et al. 2005

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Neurofibromatosis type 1 (NF1) is one of the most common genetic disorders. NF1 is a complex disease resulting from a spectrum of mutations that may occur at many locations along the large, complex NF1 gene, which is located on chromosome 17. Mutations of the NF1 gene lead to abnormal tumor suppression. Consequently, patients with NF1 have an increased prevalence of benign and malignant neoplasms throughout the body. There are five categories of NF1 tumors that occur in the abdomen: neurogenic, neuroendocrine, nonneurogenic gastrointestinal mesenchymal, embryonal, and miscellaneous. Many of these tumors are age related, occur at specific anatomic locations, and have unique imaging features. Notably, many patients have a variety of organs affected because there is a high prevalence of multiple tumors occurring in the same patient. Neurofibromas are the most common benign neoplasms and may occur in the retroperitoneum or visceral organs. Malignant peripheral nerve sheath tumor is an aggressive malignancy that is the most common malignant tumor of the abdomen in patients with NF1. Interpreting abdominal imaging studies in patients with NF1 can be challenging because of the wide spectrum and diverse nature of tumors that occur in this disease.

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Section: Neurofibroma and Plexiform Neurofibromamentioning

confidence: 99%

Abdominal Neoplasms in Patients with Neurofibromatosis Type 1: Radiologic-Pathologic Correlation

Levy¹,

Patel²,

Dow³

et al. 2005

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112

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“…In a filling defect of a pediatric bladder the differential diagnosis includes stool-filled bowel impingement, ureterocele, neurofibromatosis [10], pheochromocytoma [11], and a variety of other benign and malignant tumors, such as rhabdomyosarcoma of the bladder, which is the most common tumor of the lower urinary tract in children [12]. In adults the differential diagnosis histologically includes transitional cell carcinoma [13], squamous cell carcinoma [14], sarcoma, sarcomatoid transitional cell carcinoma and transitional spindle cell nodules, and these should be excluded by electron microscopy.…”

Section: Discussionmentioning

confidence: 99%

Hamartoma of the urinary bladder: case report and review of the literature

et al. 1999

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Bladder hamartoma is a rare benign entity with only eight cases reported in the literature thus far, and whose general imaging features have not, to our knowledge, been previously discussed. The purpose of this report is to review the literature and to discuss the imaging findings in one case of bladder hamartoma where US features were those of an inhomogeneous solid mass with an unechogenic center, which was in accordance with the CT findings of a soft tissue mass with central inhomogeneous enhancement due to central necrosis.

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“…Few reports of CT scan findings of pelvic neurofibromatosis have been published [7][8][9][10]. CT scans generally show a homogeneous mass with attenuation values of 2 0 -3 0 that may show contrast enhancement [7].…”

Section: Discussionmentioning

confidence: 99%

“…Published information regarding MRI evaluation of the plexiform neurofibromatosis is limited [8,10,11]. On Tl-weighted images, neurofibroma has a slightly greater signal intensity than muscle with hyperintense septation.…”

Section: Discussionmentioning

confidence: 99%

MRI of pelvic neurofibromatosis

et al. 1995

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Pelvic neurofibromatosis is a rare disease and rarely involves the prostate. A 19-year-old male presented with irritative and obstructive voiding symptoms. Magnetic resonance imaging showed a large mass extending from the sacral promontory to the perirectal and perivesical spaces and to the proximal root of the penis. The mass also involved the prostate. The characteristics of the mass were highly suggestive for neurofibroma. Prostate biopsy showed neurofibroma, and the immunohistochemistry stain for S-100 protein was positive.

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CT and MR of Neurofibromatosis of the Bladder

Cited by 39 publications

References 0 publications

Abdominal Neoplasms in Patients with Neurofibromatosis Type 1: Radiologic-Pathologic Correlation

Abdominal Neoplasms in Patients with Neurofibromatosis Type 1: Radiologic-Pathologic Correlation

Hamartoma of the urinary bladder: case report and review of the literature

MRI of pelvic neurofibromatosis

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