CT and PET-CT of a Dog with Multiple Pulmonary Adenocarcinoma

Abstract

A 10-year-old, intact female Yorkshire terrier had multiple pulmonary nodules on thoracic radiography and ultrasonography with no lesions elsewhere. Computed tomography (CT) and positron emission tomography and computed tomography (PET-CT) using 18F-fluorodeoxyglucose (FDG) were performed to identify metastasis and undetected primary tumors. On CT examination, pulmonary nodules had a hypoattenuating center with thin peripheral enhancement, suggesting ischemic or necrotizing lesion. In PET-CT at 47 min after intravenous injection of 11.1 MBq/kg of FDG, the maximum standardized uptake value of each pulmonary nodule was about from 3.8 to 6.4. There were no abnormal lesions except for four pulmonary nodules on the CT and PET-CT. Primary lung tumor was tentatively diagnosed, and palliative therapy using 2 mg/kg tramadol and 2.2 mg/kg carprofen twice per day was applied. After the dog’s euthanasia due to deteriorated clinical signs and poor prognosis, undifferentiated pulmonary adenocarcinoma was diagnosed through histopathologic and immunochemistry examination. To the best of the authors’ knowledge, this is the first study of CT and PET-CT features of canine pulmonary adenocarcinoma. In this case, multiple pulmonary adenocarcinoma could be determined on the basis of FDG PET-CT through screening the obvious distant metastasis and/or lymph node invasions and excluding unknown primary tumors.

Primary pulmonary adenocarcinoma in roe deer – a case report

“…The tumour measured 10 × 8 cm, which is smaller than the one we found in the roe deer (15 × 20 cm). Even smaller, multiple tumours about 3 cm in diameter were identified in the case of adenocarcinoma in dog (4). Tumours can vary in sheep from small nodules to solid masses.…”

Staging canine patients with appendicular osteosarcoma utilizing fluorine‐18 fluorodeoxyglucose positron emission tomography/computed tomography compared to whole body computed tomography

“…4,9,10 In veterinary medicine, 18 F-FDG-PET/CT has been shown to be an effective staging tool for patients with several different neoplasms, including lymphoma, mast cell tumour, mammary carcinoma, primary lung tumour, histiocytic sarcoma, Sertoli cell tumour and splenic hemangiosarcoma. 7,[11][12][13][14][15] Initial research has also shown that 18 F-FDG-PET/CT is effective for identifying both osseous and soft tissue lesions in dogs afflicted with appendicular osteosarcoma 4 and that the SUV max of the primary lesion is significantly associated with survival time. 10 However, the efficacy of 18 F-FDG-PET/CT has yet to be directly compared to other staging modalities.…”

Use of positron emission tomography in medicine and veterinary medicine

“…Znane są także warianty fizjologiczne oraz obraz charakterystyczny dla procesów łagodnych i artefaktów (17,43,47,57). W weterynarii została natomiast jedynie wstępnie opracowana ocena wartości SUV w celu różnicowania zmian łagodnych ze złośliwymi (5,29,34,36,39,43). Brak punktów odniesienia dla wartości SUV, a także stosowanie znaczników, które wykazują wysoki poziom fizjologicznej kumulacji, może dostarczać trudności interpretacyjnych (34).…”

“…Badanie PET w weterynarii, podobnie jak u ludzi, w szczególności w połączeniu z tomografią komputerową czy rezonansem magnetycznym, pozwala na uzyskanie dokładnych informacji o anatomii i metabolizmie procesu nowotworowego, a także służy różnicowaniu guzów pierwotnych i przerzutów, wykryciu ognisk przerzutów, określeniu stopnia zaawansowania choroby, zaplanowaniu i monitorowaniu przebiegu dalszego leczenia (16,19,29,34,37,39,43,59). Badanie to znalazło uznanie w różnicowaniu zmian nowotworowych i zapalnych (51).…”