2020
DOI: 10.1002/pros.24088
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CT‐based assessment of body composition following neoadjuvant chemohormonal therapy in patients with castration‐naïve oligometastatic prostate cancer

Abstract: Background The purpose of this study is to assess the body composition changes in men with recently diagnosed oligometastatic prostate cancer following neoadjuvant chemohormonal therapy. Further, we evaluated whether CT‐based body composition parameters are associated with biochemical recurrence or imaging progression. Material and methods Recently diagnosed castration‐naïve oligometastatic prostate cancer patients who received neoadjuvant docetaxel chemotherapy and androgen deprivation treatment (ADT) before … Show more

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Cited by 10 publications
(8 citation statements)
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“…The description of included studies is presented in Table 1 . Observational studies were conducted in ethnically diverse groups of PCa patients, where the sarcopenia was assessed either twice (at the baseline and in the follow up) [ 22 , 23 , 25 , 26 , 27 ] or only once during the ADT treatment [ 28 , 29 ]. The largest group of PCa patients was found in Chiang et al [ 25 ] and therefore this study will have the greatest impact on the meta-analysis performed.…”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…The description of included studies is presented in Table 1 . Observational studies were conducted in ethnically diverse groups of PCa patients, where the sarcopenia was assessed either twice (at the baseline and in the follow up) [ 22 , 23 , 25 , 26 , 27 ] or only once during the ADT treatment [ 28 , 29 ]. The largest group of PCa patients was found in Chiang et al [ 25 ] and therefore this study will have the greatest impact on the meta-analysis performed.…”
Section: Resultsmentioning
confidence: 99%
“…In most of the PCa patients, the median Gleason score was 8, indicating high-grade cancer ( Table 2 ). Patients were on different treatment regimens using ADT, where the ADT duration was reported in four studies [ 26 , 27 , 28 , 29 ] and dietary counselling was incorporated in the treatment in only one study [ 22 ] ( Table 3 ). Taking into account selected body composition parameters, an increase in SATI and VATI with a decrease in SMI and SMD over the course of ADT was observed ( Table 4 ).…”
Section: Resultsmentioning
confidence: 99%
“…Sheikhbahaei et al reported that prostate cancer patients suffer from a significant reduction in muscle mass and an increase in subcutaneous adiposity during NCRT (29). Interestingly, no apparent change in body composition was observed in our study, which is consistent with the findings of Chung et al's and De Recently, a study of 1,630 stage I to III colon cancer patients indicated that low SMA and low MD were associated with a longer length of stay and a higher risk of postsurgical complications (31).…”
Section: Discussionmentioning
confidence: 99%
“…CT-based body composition information has been used as healthy and prognostic indicators in prostate cancer. 66 This method can be extended to patients with NPC. It can be used to identify patients at risk of malnutrition.…”
Section: Prospects Of Radiomics Studies On Npcmentioning
confidence: 99%