CT Dynamics: The Shift from Morphology to Function

Mather, Richard T.

doi:10.1007/s40134-012-0004-6

Cited by 2 publications

(3 citation statements)

References 97 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The assessment of CT perfusion in calf muscles, as performed in our study, might have advantages over the perfusion measurement in the skin or muscles of the foot. We expect perfusion values obtained in muscle tissue be more reliable compared to skin-derived values, since they are more independent of ambient temperature and resistant to movement artefacts if patients are positioned properly [12, 13, 16]. However, further studies on state-of-the-art scanners are necessary to compare perfusion measurements at different levels of the leg intra-individually.…”

Section: Discussionmentioning

confidence: 99%

“…However, there are some issues in CTP that need to be addressed. The simultaneous acquisition of large volume data sets, being mandatory for limb assessment, is nowadays possible with a new generation of scanners with a larger Z -axis coverage [16]. Beam-hardening artefacts and streak artefacts from adjacent osseous structures may be solved by proper tissue segmentation, volume of interest (VOI) restraints and post-processing algorithms [17].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

CT-perfusion in peripheral arterial disease – Correlation with angiographic and hemodynamic parameters

et al. 2019

View full text Add to dashboard Cite

ObjectiveThe purpose of this study was the assessment of volumetric CT-perfusion (CTP) of the lower leg musculature in patients with symptomatic peripheral arterial disease (PAD) of the lower extremities, comparing it with established angiographic and hemodynamic parameters.Materials and methodsThirty-five consecutive patients with symptomatic PAD of the lower extremities requiring interventional revascularization were assessed prospectively. All patients underwent a CTP scan of the lower leg, and hemodynamic and angiographic assessment. Hemodynamic parameters, specifically ankle-brachial pressure index (ABI), ankle blood pressure (ABP), peak systolic velocity (PSV), and segmental pulse oscillography (SPO) level, were determined. Lesion length and degree of collateralization were assessed by interventional angiography. CTP parameters were calculated with a perfusion software, acting on a no outflow assumption. A sequential two-compartment model was used. Differences in CTP parameters and correlations between CTP, hemodynamic and angiographic parameters were assessed with non-parametric tests.ResultsThe cohort consisted of 27 subjects with an occlusion, and eight with a high-grade stenosis. The mean blood flow (BF) was 7.71 ± 2.96 ml/100ml*min-1, mean blood volume (BV) 0.71 ± 0.33 ml/100ml, and mean mean transit time (MTT) 7.22 ± 2.66 s. BF and BV were higher in subjects with longer lesions, and BV was higher in subjects with lower ABI. Significant correlations were found between lesion length and BV (r = 0.65) and BF (r = 0.52). Significant inverse correlations were found between BV and ABI and between BV and ABP (r = -0.56, for both correlations).ConclusionsIn our study, we have shown the feasibility of CTP for the assessment of PAD. In the future, this quantitative method might serve as a non-invasive method, possibly complementing the diagnostic workup of patients with peripheral arterial disease.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

CT-perfusion in peripheral arterial disease – Correlation with angiographic and hemodynamic parameters

et al. 2019

View full text Add to dashboard Cite

show abstract

“…Possible reasons for this difference might be the lower number of patients in their study, and the much smaller volume of tissue investigated in the foot, in contrast to the larger ROI in lower leg muscles in our study. We expect perfusion values obtained in lower leg muscles to be more robust, since they are more independent of ambient temperature and partly more resistant to movement artifacts, if patients are positioned properly [ 20 ]. In contrast to the abovementioned study, we did not have to exclude patients because of movement during the scan.…”

Section: Discussionmentioning

confidence: 99%

CT perfusion in peripheral arterial disease—hemodynamic differences before and after revascularisation

et al. 2021

View full text Add to dashboard Cite

Objectives The purpose of this study was the assessment of volumetric CT perfusion (CTP) of the lower leg musculature in patients with symptomatic peripheral arterial disease (PAD) before and after interventional revascularisation. Methods Twenty-nine consecutive patients with symptomatic PAD of the lower extremities requiring interventional revascularisation were assessed prospectively. All patients underwent a CTP scan of the lower leg, and hemodynamic and angiographic assessment, before and after intervention. Ankle-brachial pressure index (ABI) was determined. CTP parameters were calculated with a perfusion software, acting on a no outflow assumption. A sequential two-compartment model was used. Differences in CTP parameters were assessed with non-parametric tests. Results The cohort consisted of 24 subjects with an occlusion, and five with a high-grade stenosis. The mean blood flow before/after (BFpre and BFpost, respectively) was 7.42 ± 2.66 and 10.95 ± 6.64 ml/100 ml*min−1. The mean blood volume before/after (BVpre and BVpost, respectively) was 0.71 ± 0.35 and 1.25 ± 1.07 ml/100 ml. BFpost and BVpost were significantly higher than BFpre and BVpre in the treated limb (p = 0.003 and 0.02, respectively), but not in the untreated limb (p = 0.641 and 0.719, respectively). Conclusions CTP seems feasible for assessing hemodynamic differences in calf muscles before and after revascularisation in patients with symptomatic PAD. We could show that CTP parameters BF and BV are significantly increased after revascularisation of the symptomatic limb. In the future, this quantitative method might serve as a non-invasive method for surveillance and therapy control of patients with peripheral arterial disease. Key Points • CTP imaging of the lower limb in patients with symptomatic PAD seems feasible for assessing hemodynamic differences before and after revascularisation in PAD patients. • This quantitative method might serve as a non-invasive method, for surveillance and therapy control of patients with PAD.

show abstract

CT Dynamics: The Shift from Morphology to Function

Cited by 2 publications

References 97 publications

CT-perfusion in peripheral arterial disease – Correlation with angiographic and hemodynamic parameters

CT-perfusion in peripheral arterial disease – Correlation with angiographic and hemodynamic parameters

CT perfusion in peripheral arterial disease—hemodynamic differences before and after revascularisation

Contact Info

Product

Resources

About