CT Features of Coronavirus Disease 2019 (COVID-19) Pneumonia in 62 Patients in Wuhan, China

Zhou, Shuai; Wang, Yujin; Zhu, Tingting; Xia, Liming

doi:10.2214/ajr.20.22975

Cited by 704 publications

(804 citation statements)

References 10 publications

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“…Bilateral patchy shadows were frequently noted on chest Xray, while ground-glass opacifications are found in patients with ARDS. Typical computed tomographic (CT) findings include multiple ground-glass opacifications with or without reticular pattern, and parenchymal consolidations involving both lungs [46,47]. Other common CT features include microvascular dilatation, thick interlobar septa and air bronchogram [47].…”

Section: Pathology and Clinical Featuresmentioning

confidence: 99%

“…Typical computed tomographic (CT) findings include multiple ground-glass opacifications with or without reticular pattern, and parenchymal consolidations involving both lungs [46,47]. Other common CT features include microvascular dilatation, thick interlobar septa and air bronchogram [47]. Interestingly, CT changes have also been noted in patients before the onset of clinical symptoms and before virus RNA detection in upper respiratory specimens [48].…”

Section: Pathology and Clinical Featuresmentioning

confidence: 99%

See 1 more Smart Citation

Epidemiology, genome, and clinical features of the pandemic SARS-CoV-2: a recent view

Abduljalil

2020

New Microbes and New Infections

129

126

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Since the emergence of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in Wuhan, China, the number of globally confirmed cases according to World Health Organization statistics reached 292 124 in 189 countries by 22 March 2020. The number of deaths reached 12 784, with estimated case-fatality rates ranging from 0.5% to 5.7%. Children population seems to be the least affected by the disease, while the highest rate of death is among the elderly and people with comorbidities. Most infected individuals are asymptomatic or only exhibit mild symptoms. After the incubation period, the most common symptoms are fever, cough and fatigue.Asymptomatic carrier state is of paramount importance because of carriers' ability to spread the infection and to shed the virus into the air and surroundings. Although much is still unknown about SARS-CoV-2, the scientific research is moving at an unprecedented pace towards understanding the nature, effective control, prevention and treatment of SARS-CoV-2. Various reports have suggested an in vivo evolution of the virus, which may explain the rapid spread and changing epidemiology of SARS-CoV-2, but further evidence is needed.Unfortunately, no effective treatment or therapeutic drug is available for the disease; only supportive treatment and classical intervention measures are available for confronting the SARS-CoV-2 pandemic.

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Section: Pathology and Clinical Featuresmentioning

confidence: 99%

Section: Pathology and Clinical Featuresmentioning

confidence: 99%

Epidemiology, genome, and clinical features of the pandemic SARS-CoV-2: a recent view

Abduljalil

2020

New Microbes and New Infections

129

126

View full text Add to dashboard Cite

show abstract

“…In our routine daily practice in Lombardy region, the epicenters of COVID-19 epidemics in Italy, CT imaging resulted pervasively altered in COVID-19 patients, even in the early stages of the disease, exactly as widely reported from the recent COVID-19 outbreak in China 6,[9][10][11][12][13][14][15] As a matter of fact, chest CT has been included among the diagnostic criteria during the most rampant phase of epidemic spreading in Wuhan 16 . Notwithstanding, the effectiveness of using CT scan to triage patients with a suspected COVID-19 has been questioned for the matter of specificity, as CT signs of SARS-CoV-2 may partially overlap with other pulmonary viral infections, including influenza, H1N1, SARS and MERS.…”

Section: Computed Tomography (Ct) Role In Early Covid-19 Diagnosis: Amentioning

confidence: 87%

“…The included publications needed to be in English language and include COVID-19 patients diagnosed with RT-PCR and reporting CT findings and performances. Case reports, commentary and review were excluded, as well as studies on pediatric populations and pregnant women, leaving N=22 studies [9][10][11][12][13][14][15][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35] (Table 1). The included studies had fair and good quality scores according to "The NIH Quality Assessment Tool for Case Series Studies" 36 , sharing clear study design and aims, comparable population, clear measurement of outcome and clear description and/or representation of results.…”

Section: Ct In Covid-19 Demonstrates High Ppv and Npv Values In Condimentioning

confidence: 99%

Why is chest CT important for early diagnosis of COVID-19? Prevalence matters

Esposito

Palmisano

Morelli³

et al. 2020

Preprint

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SARS-CoV-2 viral infection is a global pandemic disease . Reaching a swift, reliable diagnosis of COVID-19 in the emergency departments is imperative to direct patients to proper care and to prevent disease dissemination. COVID-19 diagnosis is based on the identification of viral RNA through RT-PCR from oral-nasopharyngeal swabs, which however presents suboptimal sensitivity and may require several hours in overstressed laboratories. These drawbacks have called for an additional, complementary first line approach. CT is the gold standard method for the detection of interstitial pneumonia, a hallmark feature of COVID-19, often present in the asymptomatic stage of the disease. Here, we show that CT scan presents a sensitivity of 95.48% (std.err=0.35%), vastly outperforming RT-PCR. Additionally, as diagnostic accuracy is influenced by disease prevalence, we argue that predictive values provide a more precise measure of CT reliability in the current pandemics. We generated a model showing that CT scan is endowed with a high negative predictive value (> 90%) and positive predictive value (69 -84%), for the range of prevalence seen in countries with rampant dissemination. We conclude that CT is an expedite and reliable diagnostic tool to support first line triage of suspect COVID-19 patients in areas where the diffusion of the virus is widespread.

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“…1) en los planos axial (A) y coronal (B) mostraron una afectación multilobar, bilateral, con patrón predominante en vidrio deslustrado, de distribución periférica y predominio posterior, líneas subpleurales e ingurgitación vascular. Fue diagnosticada de enfermedad por coronavirus (COVID-19) [1,2]. Las imágenes se posprocesaron con un programa comercial (Pulmo3D, Syngo.Via, Siemens Healthineers), que codifica en color los percentiles de valores de atenuación, permitiendo conocer la extensión y cuantificar la carga inflamatoria (C, D).…”

unclassified

Extensión y cuantificación de la carga inflamatoria en COVID-19 mediante tomografía computarizada

Ferradas

Barrio

Bastarrika

2020

Archivos de Bronconeumología

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CT Features of Coronavirus Disease 2019 (COVID-19) Pneumonia in 62 Patients in Wuhan, China

Cited by 704 publications

References 10 publications

Epidemiology, genome, and clinical features of the pandemic SARS-CoV-2: a recent view

Epidemiology, genome, and clinical features of the pandemic SARS-CoV-2: a recent view

Why is chest CT important for early diagnosis of COVID-19? Prevalence matters

Extensión y cuantificación de la carga inflamatoria en COVID-19 mediante tomografía computarizada

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