CT findings associated with blastic plasmacytoid dendritic cell neoplasm: a case report

Jeong, Daniel; Choi, Jung Woo; Jeong, Katherine; Sokol, Lubomir

doi:10.1177/2058460116657688

Cited by 9 publications

(11 citation statements)

References 14 publications

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“…5 In addition to lymphatic spread, systemic dissemination can involve the soft tissues, the lungs and the central nervous system. 5,6 As described in this case report, the patient presented with extensive lymphadenopathy, elevated liver enzymes and pancytopenia. She is a prime example of how the diagnosis of BPDCN can be difficult, as many cases are mistaken for acute myeloid leukemia and/or cutaneous T-cell lymphoma.…”

Section: Discussionmentioning

confidence: 55%

“…In the majority of cases, CT and PET/CT images can reveal the depth of cutaneous lesions and necrosis, highlighting the specific target for biopsy. 6 Although our patient did not have multiple skin lesions that were evaluated by the CT imaging, the CT did demonstrate extensive lymphadenopathy with a high suspicion for malignancy which led to the ultimate decision to transfer the patient to a pediatric tertiary care center for pediatric oncology evaluation. The most current management for BPDCN includes treatment with tagraxofusp and, in some eligible cases, hematopoietic stem cell transplants.…”

Section: Discussionmentioning

confidence: 79%

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Investigation of a Peculiar Case of Childhood Lymphadenopathy

Aribo¹,

Al²,

Woodall³

et al. 2020

HCA Healthcare Journal of Medicine

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Introduction Lymphadenopathy is a common physical finding often associated with an infectious etiology. We present a case of a patient with generalized cervical and supraclavicular lymphadenopathy diagnosed with a rare malignancy. Health care providers should be aware of some uncommon historical or physical examination findings that warrant further investigation. Clinical Findings A 16-year-old female presented to the emergency department with 3 days of a fever, congestion and sore throat with swelling around the jaw. Her physical examination findings included bilateral mandibular swelling and generalized cervical lymphadenopathy with palpable supraclavicular lymph nodes. Outcomes Complete blood count showed pancytopenia with a white blood cell count of 4.4 x 10e3/uL, hemoglobin of 10.8 g/dL and platelets of 87 x 10e3/uL. CT scan of the neck with IV contrast revealed extensive cervical and mediastinal lymphadenopathy with suspicion of lymphoma. Biopsy results diagnosed a rare form of a hematologic malignancy called blastic plasmacytoid dendritic cell neoplasm. Conclusions The presence of supraclavicular lymphadenopathy should raise concern for non-infectious etiologies, such as malignant processes.

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Section: Discussionmentioning

confidence: 55%

Section: Discussionmentioning

confidence: 79%

Investigation of a Peculiar Case of Childhood Lymphadenopathy

Aribo¹,

Al²,

Woodall³

et al. 2020

HCA Healthcare Journal of Medicine

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“…CT has been mainly used to assess the extent and depth of the skin lesions, as well as the metastases in patients with BPDCN [4] , [5] , [6] , [7] , [8] , [9] , [10] , [11] , [12] , [13] , [14] . CT shows round and ovoid homogeneous cutaneous mass with soft tissue density with or without subcutaneous invasion as seen in the present case.…”

Section: Discussionmentioning

confidence: 99%

“…Rapid progression to the terminal leukemic phase is common, resulting in a short mean survival of 12–16 months [3] . To our knowledge, there have been at least 11 reports with CT findings [4] , [5] , [6] , [7] , [8] , [9] , [10] , [11] , [12] , [13] , [14] , including 4 18 F- fluorodeoxyglucose positron emission tomography / CT ( 18 F-FDG PET/CT) reports, associated with BPDCN; however, knowledge of chronological changes on sequential CT examinations have been limited [ 13 , 14 ]. We herein report a case of a patient with rapidly progressing BPDCN with a sequential evaluation on CT.…”

Section: Introductionmentioning

confidence: 99%

Rapidly progressing blastic plasmacytoid dendritic cell neoplasm causing diffuse skin thickening: A case report with sequential computed tomography examinations

Yoshioka

Kurokawa

Amemiya

et al. 2021

Radiology Case Reports

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Blastic plasmacytoid dendritic cell neoplasm is a rare aggressive myeloid malignancy thought to be derived from precursor plasmacytoid dendritic cells. Rapid progression and poor prognosis have been known. We herein present a case of BPDCN in a previously healthy man who presented with suddenly developed multiple deep purple skin rashes, with sequential computed tomography examinations. The follow-up computed tomography demonstrated that multiple skin nodules observed in the initial MRI fused, resulting in a thickening of the entire skin, with some surface erosions and crusting. Blastic plasmacytoid dendritic cell neoplasm should be considered in the differentials in patients with a sudden onset and rapidly progressing skin rash or thickening.

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“…Jeong et al reported lung involvement in a BPCDN patient, visualized by computed tomography. The report emphasized the importance of radiological findings in the detection of extracutaneous involvement of this disease, showing that imaging studies may help in the diagnosis of BPDCN and facilitate early treatment [ 8 ].…”

Section: Discussionmentioning

confidence: 99%

Blastic Plasmacytoid Dendritic Cell Neoplasm with Pulmonary Involvement and Atypical Skin Lesion

et al. 2017

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Patient: Female, 51Final Diagnosis: Blastic plasmacytoid dendritic cell neoplasmSymptoms: Pulmonary bleeding • small skin lesionMedication: Hyper-CVAD • methotrexate • cytarabineClinical Procedure: —Specialty: HematologyObjective:Rare diseaseBackground:Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare hematodermic malignancy neoplasm with highly aggressive course and poor prognosis. This disease typically presents with cutaneous involvement as the first manifestation, with subsequent or simultaneous spread to bone marrow and peripheral blood.Case Report:Here, we report the case of a 51-year-old woman who presented a violaceus skin lesion on the lateral region of the right thigh, weight loss, fever, and lymphadenopathies. Computed tomography (CT) displayed thoracic and abdominal lymph node and alveolar bleeding. Flow cytometry from circulating blastic cells was compatible with BPDCN (CD4+, CD56+ and CD123+). She underwent 5 cycles of hyper-CVAD alternating with high-dose methotrexate and cytarabine, but the patient died due to alveolar bleeding and sepsis.Conclusions:We report a rare case of BPDCN characterized by an aggressive course, presence of atypical skin lesion, a finding suggestive of pulmonary infiltration, and nonresponse to induction chemotherapy, leading to late diagnosis and therapeutic management. Because of the late recognition of the skin lesion, neoplastic cells infiltrated the dermis and spread as the disease progressed rapidly to a fatal course.

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CT findings associated with blastic plasmacytoid dendritic cell neoplasm: a case report

Cited by 9 publications

References 14 publications

Investigation of a Peculiar Case of Childhood Lymphadenopathy

Investigation of a Peculiar Case of Childhood Lymphadenopathy

Rapidly progressing blastic plasmacytoid dendritic cell neoplasm causing diffuse skin thickening: A case report with sequential computed tomography examinations

Blastic Plasmacytoid Dendritic Cell Neoplasm with Pulmonary Involvement and Atypical Skin Lesion

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