CT-Guided Interstitial Brachytherapy of Primary and Secondary Lung Malignancies

Peters, Nils; Wieners, Gero; Pech, Maciej; Hengst, S.; Rühl, Ricarda; Streitparth, Florian; Hänninen, Enrique Lopez; Félix, R.; Wust, Peter; Ricke, Jens

doi:10.1007/s00066-008-1718-5

Cited by 57 publications

(36 citation statements)

References 27 publications

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“…It further proves that 125 I seed implantation is feasible and safe in lung malignancies. 41,42 Locally advanced NSCLC, especially central lung carcinoma, could easily invade the pulmonary arteries and veins, and trachea. 43 During implantation, the particles may be implanted to the pulmonary arteries or trachea causing pulmonary embolism or obstructive atelectasis.…”

Section: Discussionmentioning

confidence: 99%

125I Brachytherapy in Locally Advanced Non-Small Cell Lung Cancer after Progression of Concurrent Radiochemotherapy

Xiang

Zhang

2016

Brachytherapy

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Section: Discussionmentioning

confidence: 99%

125I Brachytherapy in Locally Advanced Non-Small Cell Lung Cancer after Progression of Concurrent Radiochemotherapy

Xiang

Zhang

2016

Brachytherapy

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“…CT-HDRBT is a novel local radioablative procedure that may be carried out safely. For liver lesions [27, 31] as well as extrahepatic locations (i.e., adrenal [32], lung [33]), the feasibility, safety, and effectiveness of CT-HDRBT has been proven. A major advantage in comparison to thermal-based local ablative techniques (i.e., radiofrequency ablation) is the applicability of CT-HDRBT to tumors in close proximity to or even with circumferential growth around heat-sensitive structures (i.e., superior mesenteric artery/vein), a condition commonly present in ILMs.…”

Section: Discussionmentioning

confidence: 99%

Combined Systemic Chemotherapy and CT-Guided High-Dose-Rate Brachytherapy for Isolated Local Manifestation of Pancreatic Cancer after Surgical Resection

et al. 2018

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Background: Prospective data on the optimal management of patients with pancreatic ductal adenocarcinoma (PDA) and isolated local manifestation (ILM) after surgery are lacking. Hence, no statements with respect to this entity have been released from most international guidelines including European Society for Medical Oncology, National Comprehensive Cancer Network, and American Society for Clinical Oncology. Methods: We report for the first time a case-series of 3 patients with PDA and ILM receiving combined systemic chemotherapy and CT-guided high-dose-rate interstitial brachytherapy (CT-HDRBT). Results: CT-HDRBT allowed in all patients with pronounced chemotherapy-induced side effects either a pause of cytostatic treatment or de-escalation to a “maintenance” therapy (dose reduction, interval prolongation, scheme modification with withdrawal of most toxic drugs). Conclusion: Combining CT-HDRBT to systemic chemotherapy in patients with PDA and ILM is feasible and safe. As for patients with PDA and ILM no standard of care exists, designing an appropriate randomized prospective trial for this highly selected group of patients is challenging.

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“…Most of the published reports have used I 125 as the radiation source. [25][26][27][28][29][30] We recently reported the first use of Cs 131 seeds. The half-life of Cs 131 is of 9.7 days, and its energy is 29 Kev.…”

Section: Original Articlementioning

confidence: 99%

Limited resection followed by intraoperative seed implantation is comparable to stereotactic body radiotherapy for solitary lung cancer

Parashar¹,

Patel²,

Monni³

et al. 2010

Cancer

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BACKGROUND:The objective of this study was to compare the outcomes of patients who underwent wedge resection plus intraoperative brachytherapy versus patients who received stereotactic body radiotherapy (SBRT) for single malignant lung nodules. METHODS: A retrospective chart review included 55 patients who were treated for single lung nodules, and 47 of those patients who had adequate information were chosen for the current analysis. Twentyfive patients with single malignant lung nodules received SBRT. Twenty-two patients underwent limited surgical resection plus radioactive seed implantation for solitary malignant lung nodules. RESULTS: Univariate statistical analysis demonstrated a significance difference only for age in the 2 groups: The mean age in the radioactive seed group (66.6 years) was statistically significantly different from the mean of the age in the SBRT group (75.9 years; 2-sided P ¼ .04). No significant differences were observed between the 2 groups in terms of local control, distant metastasis, survival, or toxicity. CONCLUSIONS: The current results demonstrated comparable efficacy in outcome and toxicity between surgical resection with radioactive seed implantation and SBRT for the treatment of single malignant lung nodules in patients who were not candidates for lobectomy/pneumonectomy. Cancer 2010;116:5047-53.

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CT-Guided Interstitial Brachytherapy of Primary and Secondary Lung Malignancies

Abstract: CT-guided interstitial brachytherapy proved to be safe and effective for the treatment of primary and secondary lung malignancies.

Cited by 57 publications

References 27 publications

125I Brachytherapy in Locally Advanced Non-Small Cell Lung Cancer after Progression of Concurrent Radiochemotherapy

125I Brachytherapy in Locally Advanced Non-Small Cell Lung Cancer after Progression of Concurrent Radiochemotherapy

Combined Systemic Chemotherapy and CT-Guided High-Dose-Rate Brachytherapy for Isolated Local Manifestation of Pancreatic Cancer after Surgical Resection

Limited resection followed by intraoperative seed implantation is comparable to stereotactic body radiotherapy for solitary lung cancer

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