CT-guided percutaneous implantation of 125I particles in treatment of early lung cancer

Abstract

Background:To analyze the efficacy of computed tomography (CT)-guided implantation of 125 I radioactive particles in treatment of early lung cancer. Methods: Six patients were analyzed, including 4 squamous cell carcinoma, 1 adenocarcinoma, and 1 small cell lung cancer. TPS software was used to calculate the therapeutic dose amount of particles implanted, and the spacing and distribution of seeds in the target area and adjacent tissues. Under the guidance of CT, 20-55 particles were implanted at each site, with the total number of radioactive particles being 226, the particle spacing being 0.5-1.0 cm, and the implantation being performed in accordance with the principle of uniform implantation. The patients were each followed up with repeated pulmonary CT scans at 1, 3, 6, 12, 18, 24, 30 and 36 months after the procedure. In accordance with the response evaluation criteria in solid tumors (RECIST), the following definitions for responses were used: complete response (CR), partial response (PR), stable disease (SD), progressive disease (PD).Results: There were 2 CRs and 4 PRs one month after procedure; six patients were followed up 3 months after procedure, including 2 CRs and 4 PRs; one patient was lost in follow-up, and 5 patients were followed up 6 months after procedure, including 3 CRs and 2 PRs; five patients were followed up 12 months after procedure, including 3 CRs, 1 PR and 1 PD. The single PD patient was again given CT-guided implantation of 125 I radioactive particles for the treatment of recurrent lesions. The pulmonary CT was repeated 6 months after procedure, and the response was evaluated as SD. Four patients were followed up 18 months after procedure, including 3 CRs and 1 PR; one patient was lost in follow-up and 3 patients were followed up 24 months after the procedure with the response being evaluated as CR for all of them; one patient was followed up 36 months after procedure, and the response was evaluated as PD. During the follow-up, no serious complications occurred in any of the patients. Conclusions: The preliminary clinical observation showed that 125 I radioactive particle implantation was a safe, reliable and effective therapeutic method for early lung cancer.

RETRACTED: A study on expression level and nutritional status of IGFBP-2 after left neck anastomosis combined with placement of feeding nutritional applicators carrying ^(125)I particles in the treatment of esophageal cancer

“…In this study, a left-sided cervical anastomosis was combined with a ^(125)I particle-loaded nutrition tube. This treatment combines nutritional support and chemotherapy treatment, with (125)I particles applied to the tube and covered by the tube, allowing the particles to radiate close to the original tumor lesion, effectively removing residual tumor cells around the original tumor lesion and further enhancing its overall anti-tumor therapeutic efficacy ( 11 ). In order to investigate the therapeutic effect of left-sided cervical anastomosis combined with ^(125)I particles in esophageal cancer, this study compared the IGFBP-2 expression level and nutritional status before and after treatment of esophageal cancer and in healthy physical examination patients at the same period.…”

Computed tomography-guided iodine-125 radioactive seed implantation in small-cell lung cancer: A retrospective study

“…Iodine-125 seed implantation therapy was first used in the treatment of prostate cancer, and with the continuous innovation and improvement of medical technology, it is now widely used in treating various malignancies. Its' efficacy has been fully verified in the treatment of NSCLC [10][11][12]. A meta-study on NSCLC showed significant differences in ORR, disease control rate (DCR), and OS between 125 I brachytherapy in combination with chemotherapy and chemotherapy alone, confirming the clinical benefit of 125 I seed implantation for NSCLC treatment [14].…”

“…Iodine-125 ( 125 I) radioactive seed implantation therapy is a local treatment that has been widely used in treatment of various malignancies [7][8][9]. With the advantages of low doses, small adverse reactions, and minimal invasiveness, it has been increasingly applied in treating NSCLC, achieving certain efficacy [10][11][12]. However, this method is rarely used in SCLC treatment.…”

Prognostic Evaluation of CT Imaging Big Data-Assisted Arterial Chemoembolization Combined with 125I Seed Implantation for Non-Small-Cell Lung Cancer

“…5 Computational and Mathematical Methods in Medicine of CT imaging big data-assisted arterial chemoembolization combined with 125 I seed implantation for NSCLC was higher than arterial chemoembolization alone, without significantly increasing the incidence of adverse reactions, suggesting that the combination treatment can effectively inhibit NSCLC progression. The reason for the results may be that 125 I radioactive seeds are a kind of long half-life particles and can emit continuously low energy gamma rays, which can enhance the self-sensitization of the tumor cells and improve the sensitivity and killability of cancer cells, thus greatly improving treatment effect [19,20].…”