CT-Guided Sclerotherapy With Ethanol Concentration Monitoring for Treatment of Renal Cysts

Xu, Xiaoxue; Du, Yuchen; Yang, Han Feng; Zhang, Qing; Yang, Li; Zee, Chi Shing

doi:10.2214/ajr.10.4671

Cited by 16 publications

(19 citation statements)

References 29 publications

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“…The mean Hounsfield value of 99.9% ethanol did decrease to -190 Hounsfield units (HU) and there was a linear correlation between ethanol concentration and Hounsfield values in our previous study (5). This suggests that monitoring of the HU of ethanol by computed tomography (CT) may be an effective method in ethanol sclerotherapy of renal cysts.…”

Section: Introductionmentioning

confidence: 60%

“…Second, the concentration of ethanol in the cyst after the 2-hour retention was diluted to below the level of the coagulating effect on the cyst epithelium. The mean Hounsfield value of 99.9% ethanol went down to -190 HU (5). In our study, we observed that the aspirated cyst fluid was clear at the beginning, but the aspirated liquid became cloudy after the injection of ethanol.…”

Section: Discussionmentioning

confidence: 98%

“…Generally, most authors used from 20 to 30 minutes exposure time to ethanol in single-session sclerotherapy (1, 5-8, 11, 13). In our study, the mean ethanol exposure time was 18.7 minutes in group B, which was less than that in group A. Lin et al (15) reported that there was no statistical difference in therapeutic efficacy between 2- and 4-hour ethanol-retention techniques.…”

Section: Discussionmentioning

confidence: 99%

“…These results suggest that multiple sclerotherapy is better than a single injection of sclerosant for reducing the recurrence of simple renal cysts. High success rates of single-session aspiration and sclerotherapy have been reported (5, 6, 11). Based on those results, we chose sclerotherapy with ethanol concentration monitoring during a single-session sclerotherapy procedure as the primary treatment of simple renal cysts.…”

Section: Discussionmentioning

confidence: 99%

“…Percutaneous aspiration with single or multiple session sclerotherapy has successfully been performed with high success rates. Several sclerosing agents have been used to exterminate the cyst wall epithelium, including ethanol (1-3, 5, 6), polidocanol (4), acetic acid (7), OK-432 (8), ethanolamine oleate (9), sodium tetradecyl sulfate (10), and 20% hypertonic saline (11). …”

Section: Introductionmentioning

confidence: 99%

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CT-Guided Sclerotherapy for Simple Renal Cysts: Value of Ethanol Concentration Monitoring

Yang

et al. 2014

Korean J Radiol

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ObjectiveThe aim of our study was to evaluate the differences between sclerotherapy with and without ethanol concentration monitoring for the treatment of simple renal cysts.Materials and MethodsSixty-seven patients with 70 simple renal cysts were randomly assigned to two groups in a 12-month prospective controlled trial. One group (group A) was treated with computed tomography (CT)-guided sclerotherapy without ethanol concentration monitoring (33 patients with 35 cysts), whereas the other group (group B) had ethanol concentration monitoring (34 patients with 35 cysts) during the procedure. Treatment outcomes between the two groups were compared 12 months later with follow-up ultrasound examination.ResultsAfter the 12-month follow-up period, the overall success rate was 74.3% in group A and 94.3% in group B (p = 0.022). The mean cyst size before and after treatment was 8.6 ± 2.0 cm and 2.3 ± 2.9 cm, respectively, in group A, and 8.4 ± 1.7 cm and 0.8 ± 1.9 cm, respectively, in group B. The final size of the cysts in group B was significantly smaller than that in group A (p = 0.015). The likelihood of treatment with ethanol concentration monitoring being successful was approximately 16 times higher than without ethanol concentration monitoring (p = 0.026; odds ratio = 15.7; 95% confidence interval: 1.38-179.49). There were no major complications in either group.ConclusionMonitoring of Hounsfield units (HU) of ethanol by CT is an effective method in the treatment of simple renal cysts with ethanol sclerotherapy. The ethanol sclerotherapy procedure can be terminated at the point of clear fluid aspiration because the HU (-190) of CT scan corresponds to it.

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Section: Introductionmentioning

confidence: 60%

Section: Discussionmentioning

confidence: 98%